Evidence map›Paper›PMID 37643353›Full record

ArticleJournal of natural products2023

Probing the Cytotoxic Signaling Induced by Eupenifeldin in Ovarian Cancer Models.

Amanda C Maldonado, Monica A Haughan, Manead Khin, Julia Ekiert, Ziwei Zhang, Daniel Lantvit, Zeinab Y Al Subeh, Herma C Pierre, Maryna Salkovski, Tal Hirschhorn and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of natural products, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Amanda C MaldonadoChicago Biomedical Consortium, Northwestern University, Evanston, Illinois 60208, United States.
Monica A HaughanPharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.ORCID 0009-0006-8581-2332
Manead KhinPharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-5744-9584
Julia EkiertPharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Ziwei ZhangPharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Daniel LantvitPharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Zeinab Y Al SubehDepartment of Medicinal Chemistry and Pharmacognosy, Jordan University of Science and Technology, Irbid 22110, Jordan.ORCID 0000-0001-9051-4969
Herma C PierreDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
Maryna SalkovskiDepartment of Chemistry, College of Liberal Arts and Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Tal HirschhornDepartment of Biological Sciences, Columbia University, New York, New York 10027, United States.
Yu GaoPharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0003-3220-4721
Cedric J PearceMycosynthetix Inc., Hillsborough, North Carolina 27278, United States.
Brent R StockwellDepartment of Biological Sciences, Columbia University, New York, New York 10027, United States.
Leslie N AldrichDepartment of Chemistry, College of Liberal Arts and Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0001-8406-720X
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
Joanna E BurdettePharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-7271-6847
University of Illinois Chicago · USColumbia University · USUniversity of North Carolina at Greensboro · USJordan University of Science and Technology · JOMycosynthetix (United States) · USNorthwestern University · US

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2M
Defining the functions and translational potential of ferroptosisR35CA209896 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STOCKWELL, BRENT R. · 2016 to 2022
$6.5M
Research Training in Natural Product Complementary and Integrative HealthT32AT007533 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, JIMMY ORJALA · 2013 to 2026
$4.3M
Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine ResearchT32AT008938 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Nadja B Cech, Jonathan Rodi Chekan · 2016 to 2026
$1.6M
NCCIH NIH HHS T32 AT007533NCCIH NIH HHS T32 AT008938NCI NIH HHS P01 CA125066NCI NIH HHS R35 CA209896
6 · The paper itself

Abstract

High-grade serous ovarian cancer (HGSOC) is the most common and lethal ovarian cancer histotype. Lack of early detection methods, limited therapeutic agents, and low 5-year survival rate reflect the urgent need to develop new therapies. Eupenifeldin, a bistropolone, originally isolated from

Indexed as

Antineoplastic AgentsOvarian NeoplasmsApoptosisCell Line, TumorFemaleHumansTropoloneAntineoplastic AgentseupenifeldinTropolone

Identifiers

PMID37643353
PMCPMC10792992
OpenAlexW4386244592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.