Evidence map›Paper›PMID 37643291›Full record

Trial reportDiabetes care2024

Impact of Gestational Diabetes Detection Thresholds on Infant Growth and Body Composition: A Prospective Cohort Study Within a Randomized Trial.

Komal Manerkar, Caroline A Crowther, Jane E Harding, Michael P Meyer, Cathryn A Conlon, Elaine C Rush, Jane M Alsweiler, Lesley M E McCowan, Janet A Rowan, Richard Edlin and 2 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetes care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Komal ManerkarLiggins Institute, University of Auckland, Auckland, New Zealand.
Caroline A CrowtherLiggins Institute, University of Auckland, Auckland, New Zealand.
Jane E HardingLiggins Institute, University of Auckland, Auckland, New Zealand.
Michael P MeyerTe Whatu Ora, Counties Manukau, Auckland, New Zealand.
Cathryn A ConlonSchool of Sport, Exercise and Nutrition, Massey University, Auckland, New Zealand.
Elaine C RushSchool of Sport and Recreation, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.
Jane M AlsweilerDepartment of Paediatrics: Child and Youth Health, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-0874-6654
Lesley M E McCowanDepartment of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.
Janet A RowanTe Whatu Ora, Te Toka Tumai Auckland, Auckland, New Zealand.ORCID 0000-0001-8406-3452
Richard EdlinHealth Systems, University of Auckland, Auckland, New Zealand.
Francesca AmitranoLiggins Institute, University of Auckland, Auckland, New Zealand.
Christopher J D McKinlayTe Whatu Ora, Counties Manukau, Auckland, New Zealand.ORCID 0000-0003-1088-9467
University of Auckland · NZAuckland University of Technology · NZMassey University · NZ

Funding

Auckland Medical Research FoundationCounties Manukau Te Whatu Ora, Tupu FundCure KidsHealth Research Council of New ZealandLotteries HealthNurture Foundation for Reproductive Research
6 · The paper itself

Abstract

objectiveGestational diabetes mellitus (GDM) is associated with offspring metabolic disease, including childhood obesity, but causal mediators remain to be established. We assessed the impact of lower versus higher thresholds for detection and treatment of GDM on infant risk factors for obesity, including body composition, growth, nutrition, and appetite. RESEARCH DESIGN AND

methodsIn this prospective cohort study within the Gestational Diabetes Mellitus Trial of Diagnostic Detection Thresholds (GEMS), pregnant women were randomly allocated to detection of GDM using the lower criteria of the International Association of Diabetes and Pregnancy Study Groups or higher New Zealand criteria (ACTRN12615000290594). Randomly selected control infants of women without GDM were compared with infants exposed to A) GDM by lower but not higher criteria, with usual treatment for diabetes in pregnancy; B) GDM by lower but not higher criteria, untreated; or C) GDM by higher criteria, treated. The primary outcome was whole-body fat mass at 5-6 months.

resultsThere were 760 infants enrolled, and 432 were assessed for the primary outcome. Fat mass was not significantly different between control infants (2.05 kg) and exposure groups: A) GDM by lower but not higher criteria, treated (1.96 kg), adjusted mean difference (aMD) -0.09 (95% CI -0.29, 0.10); B) GDM by lower but not higher criteria, untreated (1.94 kg), aMD -0.15 (95% CI -0.35, 0.06); and C) GDM detected and treated using higher thresholds (1.87 kg), aMD -0.17 (95% CI -0.37, 0.03).

conclusionsGDM detected using lower but not higher criteria, was not associated with increased infant fat mass at 5-6 months, regardless of maternal treatment. GDM detected and treated using higher thresholds was also not associated with increased fat mass at 5-6 months.

Indexed as

Diabetes, GestationalPediatric ObesityBirth WeightBody CompositionChildFemaleHumansInfantPregnancyProspective Studies

Identifiers

PMID37643291
OpenAlexW4386241841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.