Evidence map›Paper›PMID 37643288›Full record

ArticleACS nano2023

Quantitation of Circulating

Xiaoqin Wang, Xiaojun Wei, Marieke M van der Zalm, Zehui Zhang, Nandhini Subramanian, Anne-Marie Demers, Elisabetta Ghimenton Walters, Anneke Hesseling, Chang Liu

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 4 countries.

Xiaoqin WangDepartment of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.
Xiaojun WeiDepartment of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0002-6229-6228
Marieke M van der ZalmDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 8000, South Africa.ORCID 0000-0002-8787-9139
Zehui ZhangBiomedical Engineering Program, University of South Carolina, Columbia, South Carolina 29208, United States.
Nandhini SubramanianBiomedical Engineering Program, University of South Carolina, Columbia, South Carolina 29208, United States.
Anne-Marie DemersDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 8000, South Africa.
Elisabetta Ghimenton WaltersDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 8000, South Africa.
Anneke HesselingDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 8000, South Africa.
Chang LiuDepartment of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0001-8097-9631
University of South Carolina · USDesmond Tutu HIV Foundation · ZA

Funding

Nanopore-Based HIV Self-Test for Ultrasensitive p24 Quantification in FingerPrick BloodR61AI174295 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LIU, CHANG · 2023 to 2025
$1.2M
The long-term consequences of pulmonary tuberculosis and respiratory viruses on lung health in young South African childrenK43TW011028 · FIC · STELLENBOSCH UNIVERSITY · PI VAN DER ZALM, MARIEKE MARGREET · 2020 to 2024
$647k
A Solid-State Nanopore Biosensor for Rapid Detection of Mycobacterium tuberculosis Antigens in Pediatric Blood SamplesK22AI136686 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LIU, CHANG · 2019 to 2020
$265k
FIC NIH HHS K43 TW011028NIAID NIH HHS K22 AI136686NIAID NIH HHS R61 AI174295
6 · The paper itself

Abstract

Nanopore sensing of proteomic biomarkers lacks accuracy due to the ultralow abundance of targets, a wide variety of interferents in clinical samples, and the mismatch between pore and analyte sizes. By converting antigens to DNA probes via click chemistry and quantifying their characteristic signals, we show a nanopore assay with several amplification mechanisms to achieve an attomolar level limit of detection that enables quantitation of the circulating

Indexed as

Mycobacterium tuberculosisNanoporesTuberculosisTuberculosis, PulmonaryAntigens, BacterialChildHumansProteomicsSensitivity and SpecificitySouth AfricaAntigens, BacterialMycobacterium tuberculosis antigensblood testCFP-10ESAT-6nanoporepediatric tuberculosis

Identifiers

PMID37643288
PMCPMC10668583
OpenAlexW4386249195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.