Evidence map›Paper›PMID 37643212›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by

Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar de Rojas, Thiago Peixoto Leal, Akinori Miyashita and 140 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01315639 (Plasma Abeta Peptides and the Risk of Alzheimer's Disease. Diagnostic Performance and Predictive and Prognostic Values of Measurements of Plasma Amyloid Peptides Concentrations for the Diagnosis of Alzheimer's Disease), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01315639 nacompletednot on this map

Plasma Abeta Peptides and the Risk of Alzheimer's Disease. Diagnostic Performance and Predictive and Prognostic Values of Measurements of Plasma Amyloid Peptides Concentrations for the Diagnosis of Alzheimer's Disease

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2010 to 2018Enrolled1,067ConditionsAlzheimer's Disease, Mild Cognitive ImpairmentArmsbiomarkers, MRI and CSF
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Article
  6. Review
  7. UnlockingNAR genomics and bioinformatics · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Progress of Immunotherapies in Parkinson's Disease.CNS neuroscience & therapeutics · 2026
    Review
  14. Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  15. Shared Epitope-PositiveNeurology(R) neuroimmunology & neuroinflammation · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

150 authors at 20 institutions in 21 countries.

Yann Le Guen *Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, CA.ORCID 0000-0001-6649-8364
Guo Luo *Center for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.
Aditya Ambati *Center for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.
Vincent Damotte *Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille 59000, France.ORCID 0000-0002-7321-8575
Iris JansenDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Eric YuThe Neuro (Montreal Neurological Institute-Hospital), Montreal, Quebec H3A 2B4, Canada.
Aude NicolasUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille 59000, France.
Itziar de RojasResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona 08029, Spain.
Thiago Peixoto LealGenomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland 44196, OH.
Akinori MiyashitaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 950-218, Japan.
Céline BellenguezUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille 59000, France.
Michelle Mulan LianLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore 308232, Singapore.
Kayenat ParveenDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany.
Takashi MorizonoMedical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Hyeonseul ParkDepartment of Biomedical Science, Chosun University, Gwangju 61452, Korea.
Benjamin Grenier-BoleyUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille 59000, France.
Tatsuhiko NaitoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Fahri KüçükaliComplex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp 2610, Belgium.
Seth D TalyanskyDepartment of Neurology and Neurological Sciences, Stanford University, Stanford 94305, CA.
Selina Maria YogeshwarCenter for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.
Vicente SempereCenter for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.
Wataru SatakeDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 192-0982, Japan.
Victoria AlvarezLaboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo 33011, Spain.
Beatrice ArosioDepartment of Clinical Sciences and Community Health, University of Milan, Milan 20122, Italy.
Michael E BelloyDepartment of Neurology and Neurological Sciences, Stanford University, Stanford 94305, CA.
Luisa BenussiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia 25125, Italy.
Anne BolandUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry 91057, France.
Barbara BorroniDepartment of Clinical and Experimental Sciences, Centre for Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia 25123, Italy.
María J BullidoNetworking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain.
Paolo CaffarraUnit of Neurology, University of Parma and AOU, Parma 43121, Italy.
Jordi ClarimonNetworking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain.
Antonio DanieleDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Daniel DarlingCenter for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.
Stéphanie DebetteUniversity Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux 33000, France.
Jean-François DeleuzeUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry 91057, France.
Martin DichgansInstitute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University of Munich, 81377, Munich, Germany.
Carole DufouilInserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux 33405, France.
Emmanuel DuringCenter for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.ORCID 0000-0002-0539-5115
Emrah DüzelGerman Center for Neurodegenerative Diseases, Magdeburg 39120, Germany.
Daniela GalimbertiNeurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan 20122, Italy.
Guillermo Garcia-RibasHospital Universitario Ramon y Cajal, IRYCIS, Madrid 28034, Spain.
José María García-AlbercaNetworking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain.
Pablo García-GonzálezResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona 08029, Spain.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala 751 22, Sweden.
Oliver GoldhardtDepartment of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Klinikum recs der Isar, Munich 80333, Germany.
Caroline GraffUnit for Hereditary Dementias, Theme Aging, Karolinska University Hospital-Solna, Stockholm 171 64, Swdeen.
Edna GrünblattDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland.
Olivier HanonUniversité de Paris, EA 4468, APHP, Hôpital Broca, Paris 75013, France.
Lucrezia HausnerDepartment of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg 68159, Germany.
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn 53127, Germany.
Henne HolstegeDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Jakub HortDepartment of Neurology, Memory Clinic, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague 150 06, Czech Republic.ORCID 0000-0002-1080-3726
Yoo Jin JungStanford Neurosciences Interdepartmental Program, Stanford University School of Medicine, Stanford 94305, CA.
Deckert JürgenDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg 97080, Germany.
Silke KernDepartment of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg 405 30, Sweden.
Teemu KuulasmaaInstitute of Biomedicine, University of Eastern Finland, Joensuu, Kuopio, Eastern Finland 80101, Finland.
Kun Ho LeeDepartment of Biomedical Science, Chosun University, Gwangju 61452, Republic of Korea.
Ling LinCenter for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.ORCID 0000-0002-3406-0058
Carlo MasulloInstitute of Neurology, Catholic University of the Sacred Heart, Rome 20123, Italy.
Patrizia MecocciDepartment of Medicine and Surgery, Institute of Gerontology and Geriatrics, University of Perugia, Perugia 06123, Italy.
Shima MehrabianClinic of Neurology, UH "Alexandrovska", Medical University-Sofia, Sofia 1431, Bulgaria.
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon 1649-028, Portugal.
Mercè BoadaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona 08029, Spain.
Pablo MirNetworking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain.
Susanne MoebusInstitute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen 45147, Germany.
Fermin MorenoNetworking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence 50121, Italy.
Gael NicolasDepartment of Genetics and CNR-MAJ, Normandie Univ, UNIROUEN, Inserm U1245 and CHU Rouen, Rouen F-76000, France.
Shumpei NiidaMedical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.ORCID 0000-0002-6192-8035
Børge G NordestgaardDepartment of Clinical Biochemistry, Copenhagen University Hospital-Herlev Gentofte, Copenhagen 2730, Denmark.
Goran PapenbergDepartment of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm 171 77, Sweden.
Janne PapmaDepartment of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam 3000, The Netherlands.
Lucilla ParnettiCentre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia 06123, Italy.
Florence PasquierUniversité de Lille, Inserm 1172, CHU Clinical and Research Memory Research Centre of Distalz, Lille 59000, France.ORCID 0000-0001-9880-9788
Pau PastorFundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona 08221, Spain.
Oliver PetersGerman Center for Neurodegenerative Diseases (DZNE), Berlin 37075, Germany.
Yolande A L PijnenburgDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Gerard Piñol-RipollUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida 25198, Spain.
Julius PoppDepartment of Psychiatry, Old Age Psychiatry, Lausanne University Hospital, Lausanne 1005, Switzerland.
Laura Molina PorcelNeurological Tissue Bank-Biobanc- Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona 08036, Spain.
Raquel PuertaResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona 08029, Spain.
Jordi Pérez-TurNetworking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain.
Innocenzo RaineroDepartment of Neuroscience "Rita Levi Montalcini", University of Torino, Torino 10126, Italy.
Inez RamakersDepartment of Psychiatry and Neuropsychologie, Alzheimer Center Limburg, Maastricht University, Maastricht 6229 GS, The Netherlands.
Luis M RealUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla 41014, Spain.ORCID 0000-0003-4932-7429
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig 04109, Germany.
Eloy Rodriguez-RodriguezNetworking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain.
Owen A RossDepartment of Neuroscience, Mayo Clinic-Florida, Jacksonville 32224, FL.
Luis Jose RoyoDepatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina, Universidad de Málaga, Málaga 29010, Spain.
Dan RujescuMartin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale) 06120, Germany.ORCID 0000-0002-1432-313X
Nikolaos ScarmeasDepartment of Neurology, The Gertrude H. Sergievsky Center, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York 10032, NY.
Philip ScheltensDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Norbert ScherbaumDepartment of Psychiatry and Psychotherapy, Medical Faculty, LVR-Hospital Essen, University of Duisburg-Essen, 45147 Duisberg, Germany.
Anja SchneiderGerman Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen), 37075 Göttingen, Germany.
Davide SeripaDepartment of Hematology and Stem Cell Transplant, Laboratory for Advanced Hematological Diagnostics, Lecce 73100, Italy.
Ingmar SkoogDepartment of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg 405 30, Sweden.
Vincenzo SolfrizziInterdisciry Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari "A. Moro, Bari 70121, Italy.
Gianfranco SpallettaLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome 00179, Italy.ORCID 0000-0002-7432-4249
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari 09124, Italy.
John van SwietenDepartment of Neurology, ErasmusMC, Rotterdam 3000 CA, Netherlands.
Raquel Sánchez-ValleAlzheimer's disease and other cognitive disorders unit, Service of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona 08036, Spain.
Eng-King TanDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore 308433, Singapore.
Thomas Tegos1st Department of Neurology, Medical school, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece.
Charlotte TeunissenNeurochemistry Lab, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, Netherlands.
Jesper Qvist ThomassenDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen 2100, Denmark.
Lucio TremolizzoNeurology, "San Gerardo" hospital, Monza and University of Milano-Bicocca, Monza 20900, Italy.
Martin VyhnalekDepartment of Clinical Genetics, VU University Medical Centre, Amsterdam 1081 HV, The Netherlands.
Frans VerheyDepartment of Psychiatry and Neuropsychologie, Alzheimer Center Limburg, Maastricht University, Maastricht 6229 GS, Netherlands.
Margda WaernNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg 431 41, Sweden.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen 37075, Germany.
Jing ZhangCenter for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.
EADB
GR@ACE study group
DEGESCO consortium
DemGene
EADI
GERAD
Asian Parkinson’s Disease Genetics consortium
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal 431 41, Sweden.ORCID 0000-0003-3930-4354
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal 431 41, Sweden.
Zihuai HeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford 94305, CA.
Julie WilliamsUKDRI@Cardiff, School of Medicine, Cardiff University, Wales CF14 4YS, United Kingdom.
Philippe AmouyelUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille 59000, France.
Frank JessenGerman Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen), 37075 Göttingen, Germany.
Patrick G KehoeTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1QU, United Kingdom.
Ole A AndreassenNORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0450, Norway.ORCID 0000-0002-4461-3568
Cornelia Van DuinDepartment of Epidemiology, ErasmusMC, Rotterdam 3000 CA, The Netherlands.
Magda Tsolaki1st Department of Neurology, Medical school, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece.ORCID 0000-0002-2072-8010
Pascual Sánchez-JuanNetworking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain.
Ruth Frikke-SchmidtDepartment of Clinical Medicine, University of Copenhagen, Copenhagen 1172, Denmark.
Kristel SleegersComplex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp 2610, Belgium.
Tatsushi TodaDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 192-0982, Japan.
Anna ZettergrenNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg 431 41, Sweden.
Martin IngelssonDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala 751 22, Sweden.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Giacomina RossiFondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy.
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Joensuu, Kuopio, Eastern Finland 80101, Finland.
Jungsoo GimDepartment of Biomedical Science, Chosun University, Gwangju 61452, Korea.
Kouichi OzakiMedical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Rebecca SimsDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales CF14 4YS, United Kingdom.
Jia Nee FooLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore 308232, Singapore.ORCID 0000-0001-9899-2308
Wiesje van der FlierDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 950-218, Japan.
Alfredo RamirezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany.
Ignacio MataGenomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland 44196, OH.
Agustín RuizResearch Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona 08029, Spain.
Ziv Gan-OrThe Neuro (Montreal Neurological Institute-Hospital), Montreal, Quebec H3A 2B4, Canada.
Jean-Charles Lambert *Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille 59000, France.
Michael D Greicius *Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, CA.
Emmanuel Mignot *Center for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA.ORCID 0000-0002-6928-5310
Instituto de Salud Carlos III · ESInserm · FRStanford University · USAmsterdam Neuroscience · NLGerman Center for Neurodegenerative Diseases · DEUniversity of Cologne · DEFundació ACE · ESCardiff University · GBAgency for Science, Technology and Research · SGErasmus MC · NLSahlgrenska University Hospital · SEUniversité de Bordeaux · FRUniversity of Copenhagen · DKUniversity of Duisburg-Essen · DEUniversity of Eastern Finland · FIUppsala University · SECharles University · CZChosun University · KRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRMaastricht University · NL

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
Statistical and computational methods for integrative analysis of Alzheimer's Disease geneticsR01AG066206 · NIA · STANFORD UNIVERSITY · PI HE, ZIHUAI · 2019 to 2023
$3.5M
The Stanford Extreme Phenotypes in Alzheimer's Disease (StEP AD) CohortR01AG060747 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2018 to 2022
$3.4M
Modeling the impact of Women's Specific Health Factors in PD outcomes in LatinasR01NS112499 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FERNANDEZ MATA, IGNACIO · 2020 to 2024
$3.3M
Medical Research Council MR/L010305/1Medical Research Council MR/T04604X/1NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG060747NIA NIH HHS R01 AG066206NIA NIH HHS U24 AG021886NINDS NIH HHS R01 NS112499
6 · The paper itself

Abstract

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of

Indexed as

Alzheimer DiseaseHLA-DRB1 ChainsParkinson DiseaseHistocompatibility AntigensHLA AntigensHumansHistocompatibility AntigensHLA AntigensHLA-DRB1*04 antigenHLA-DRB1 ChainsAlzheimer’s dementiaautoimmunityHLAneurodegenerationParkinson’s disease

Identifiers

PMID37643212
PMCPMC10483635
OpenAlexW4386249643

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.