Evidence map›Paper›PMID 37642998›Full record

ArticleThe Journal of experimental medicine2023

Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1.

Ryan Tibble, Marisa A Yonemitsu, Patrick S Mitchell

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryan Tibble *Department of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4188-3116
Marisa A Yonemitsu *Molecular and Cellular Biology Graduate Program, University of Washington , Seattle, WA, USA.
Patrick S MitchellDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8375-9060
University of Washington · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
NIDDK NIH HHS P30 DK089507NIGMS NIH HHS T32 GM136534
6 · The paper itself

Abstract

In this issue of JEM, companion articles from Pinilla et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230104) and Robinson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230105) demonstrate that ribotoxic stress induced by Pseudomonas aeruginosa and Corynebacterium diphtheriae EEF2-targeting exotoxins leads to NLRP1 inflammasome activation, representing a new mechanism of effector-triggered immunity.

Indexed as

ExotoxinsInflammasomesHumansInnate Immunity RecognitionMemory DisordersNLR ProteinsExotoxinsInflammasomesNLRP1 protein, humanNLR Proteins

Identifiers

PMID37642998
PMCPMC10465322
OpenAlexW4386250676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.