ArticleInternational urology and nephrology2024
Association between albumin-corrected anion gap level and the risk of acute kidney injury in intensive care unit.
Article in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Predictive Value of Anion Gap for Acute Kidney Injury Progression and Outcomes.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Predictive Value of 48-hour Anion Gap Fluctuations in ICU Patients with Acute Kidney Injury: An Analysis based on MIMIC Database.Current pharmaceutical design · 2026Article
- Association Between Albumin-Corrected Anion Gap and Mortality in ICU Patients With Acute Heart Failure: A MIMIC-IV Cohort Study.Cardiovascular therapeutics · 2026Article
- Prognostic value of albumin-corrected anion gap in severe chronic kidney disease with sepsis: association with mortality and clinical outcomes.European journal of medical research · 2025Article
- Relationship between time-weighted average anion gap and mortality in septic shock patients: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Article
- Association of elevated albumin-corrected anion gap with all-cause mortality risk in atrial fibrillation: a retrospective study.BMC cardiovascular disorders · 2025Article
- Article
- The relationship between albumin-corrected anion gap and hyperuricemia and its role in cardiovascular risk assessment: mediation effect analysis of triglycerides and non-high-density lipoproteins.Frontiers in endocrinology · 2025Article
- Association of albumin-corrected anion gap with severe consciousness disorders and outcomes in ischemic stroke: a retrospective MIMIC analysis.Scientific reports · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was to investigate the association between albumin-corrected anion gap (AG) (ACAG) levels and the risk of acute kidney injury (AKI) in intensive care unit (ICU) patients.
methodsThe ICU patients of this retrospective cohort study were collected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database between 2008 and 2019. ACAG = AG + {4.4 - [albumin (g/dl)]} × 2.5. The incidence of AKI was determined using the Kidney Disease: Improving Global Outcomes (KDIGO) definition. The logistic regression model was used to evaluate the association between ACAG levels and the risk of AKI. Subgroup analyses were applied based on age, gender, mechanical ventilation, vasopressors, the Charlson comorbidity index (CCI), and the Simplified Acute Physiology Score II (SAPS II).
resultsTotally, 5586 patients were enrolled, of which 1929 patients (34.53%) occurred AKI. The higher levels of ACAG were associated with the risk of AKI in ICU patients, with the odds ratio (OR) value being 1.23 [95% confidence interval (CI): 1.22-1.24, P = 0.005] in ACAG level between 16.5 and 19.5, and OR value being 1.20 (95% CI 1.16-1.24, P = 0.016) in ACAG level > 19.5. A higher ACAG level was associated with a higher risk of AKI in ICU patients aged < 65 years, in ICU patients of female gender, in ICU patients who used mechanical ventilation, in ICU patients who did not use vasopressors, in patients without cardiogenic shock, and in ICU patients with CCI ≥ 2, and SAPS II > 31 (all P < 0.05).
conclusionThere is an association between ACAG level and the risk of AKI in ICU patients. A higher ACAG value in ICU patients should therefore receive more attention.
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