Evidence map›Paper›PMID 37642731›Full record

ReviewVirchows Archiv : an international journal of pathology2023

Predictive value of tumor budding in head and neck squamous cell carcinoma: an update.

Carlos M Chiesa-Estomba, Lester Thompson, Abbas Agaimy, Nina Zidar, Roderick H W Simpson, Alessandro Franchi, Juan P Rodrigo, Antti A Mäkitie, Alhadi Almangush, Ilmo Leivo and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 7 countries.

Carlos M Chiesa-EstombaDepartment of Otorhinolaryngology, Osakidetza, Donostia University Hospital, Biodonostia Research Institute, 20014, San Sebastian, Spain. chiesaestomba86@gmail.com.ORCID http://orcid.org/0000-0001-9454-9464
Lester ThompsonHead and Neck Pathology Consultations, Woodland Hills, CA, 91364, USA.
Abbas AgaimyInstitut Für Pathologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Nina ZidarInstitute of Pathology, Faculty of Medicine, University of Ljubljana, 1000, Ljubljana, Slovenia.
Roderick H W SimpsonDepartment of Anatomical Pathology, University of Calgary, Calgary, AB, Canada.
Alessandro FranchiDepartment of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, 56126, Pisa, Italy.
Juan P RodrigoDepartment of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Oviedo, Spain.
Antti A MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, Research Program in Systems Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Alhadi AlmangushResearch Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ilmo LeivoInstitute of Biomedicine, Pathology, University of Turku, Turku, Finland.
Alfio FerlitoCoordinator of the International Head and Neck, Scientific Group, Padua, Italy.
University of Helsinki · FIFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversidad de Deusto · ESUniversidad de Oviedo · ESUniversity of Calgary · CAUniversity of Ljubljana · SIUniversity of Pisa · ITUniversity of Turku · FIWoodland Hills Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma forms an anatomically and functionally complex group of malignancies. The significant local aggressiveness and frequent regional relapses motivate ongoing research to identify more reliable and sensitive prognostic and predictive biomarkers. One emerging area of cancer biology is the evaluation of tumor budding at the advancing invasive front of various types of epithelial cancers. Recent studies suggest that tumor budding is a relatively common phenomenon in cancer progression and that it may have important prognostic implications for patients due to its potential to provide valuable insights into the biology and clinical behavior of head and neck cancer. In this review, we aim to provide information about tumor budding in head and neck squamous cell carcinoma. Thus, we hope to shed light on the complex biology of these malignancies, as well as aiding diagnostic, classification, and better characterization and thereby, looking for new avenues for improving patient outcomes.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsBiomarkers, TumorHumansNeoplasm InvasivenessNeoplasm Recurrence, LocalSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorBuddingCancerHeadNeckTumor

Identifiers

PMID37642731
OpenAlexW4386253693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.