Evidence map›Paper›PMID 37642674›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

IL-17A neutralization fails to attenuate airway remodeling and potentiates a proinflammatory lung microenvironment in diacetyl-exposed rats.

Emma L House, So-Young Kim, David Chalupa, Eric Hernady, Angela M Groves, Carl J Johnston, Matthew D McGraw

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Emma L HouseDepartment of Pathology, University of Rochester Medical Center, Rochester, New York, United States.
So-Young KimDepartment of Pediatrics, Division of Pediatric Pulmonology, University of Rochester Medical Center, Rochester, New York, United States.ORCID 0000-0001-8724-9770
David ChalupaDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Eric HernadyDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Angela M GrovesDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States.ORCID 0000-0003-1810-5532
Carl J JohnstonDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Matthew D McGrawDepartment of Pediatrics, Division of Pediatric Pulmonology, University of Rochester Medical Center, Rochester, New York, United States.ORCID 0000-0002-5646-3560
University of Rochester Medical Center · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Institutional Career Development CoreKL2TR001999 · NCATS · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2016 to 2024
$5.2M
Mechanisms of Basal Cell Dysfunction in Chemical-induced Bronchiolitis ObliteransK08ES033290 · NIEHS · UNIVERSITY OF ROCHESTER · PI MCGRAW, MATTHEW DANIEL · 2022 to 2025
$936k
NCATS NIH HHS KL2 TR001999NIEHS NIH HHS K08 ES033290NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

Bronchiolitis obliterans (BO) is a devastating lung disease that can develop following inhalation exposure to certain chemicals. Diacetyl (DA) is one chemical commonly associated with BO development when inhaled at occupational levels. Previous studies in rats have shown that repetitive DA vapor exposures increased lung CD4

Indexed as

Bronchiolitis ObliteransInterleukin-17Airway RemodelingAnimalsDiacetylImmunoglobulin GLungNF-kappa BRatsRats, Sprague-DawleyTumor Necrosis Factor-alphaDiacetylImmunoglobulin GInterleukin-17NF-kappa BTumor Necrosis Factor-alphaairwaybronchiolitis obliteransCD4+ T celldiacetylinterleukin-17A (IL-17A)

Identifiers

PMID37642674
PMCPMC10639012
OpenAlexW4386250740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.