Evidence map›Paper›PMID 37642652›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at

Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Shana Kahnamoui, Bo Xiang and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Chinonye Doris OnuzuluDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0001-9054-6565
Samantha LeeDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
Sujata BasuChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Jeannette ComteChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Yan HaiDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
Nikho HizonDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
Shivam ChadhaDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
Maria Shenna FauniDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
Shana KahnamouiChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Bo XiangChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Andrew J HalaykoChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0002-7865-4552
Vernon W DolinskyChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0001-5191-4628
Christopher D PascoeChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0002-5229-9927
Meaghan J JonesDepartment of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0003-1593-997X
Children's Hospital Research Institute of Manitoba · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal and early-life exposure to cigarette smoke (CS) has repeatedly been shown to induce stable, long-term changes in DNA methylation (DNAm) in offspring. It has been hypothesized that these changes might be functionally related to the known outcomes of prenatal and early-life CS exposure, which include impaired lung development, altered lung function, and increased risk of asthma and wheeze. However, to date, few studies have examined DNAm changes induced by prenatal CS in tissues of the lung, and even fewer have attempted to examine the specific influences of prenatal versus early postnatal exposures. Here, we have established a mouse model of CS exposure which isolates the effects of prenatal and early postnatal CS exposures in early life. We have used this model to measure the effects of prenatal and/or postnatal CS exposures on lung function and immune cell infiltration as well as DNAm and expression of

Indexed as

Cigarette SmokingPrenatal Exposure Delayed EffectsAnimalsCytochrome P-450 CYP1A1DNA MethylationFemaleHumansLungMiceNicotianaPregnancyCytochrome P-450 CYP1A1cigarette smokeDNA methylationearly lifelung functionpriming

Identifiers

PMID37642652
PMCPMC11068412
OpenAlexW4386250720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.