Evidence map›Paper›PMID 37642646›Full record

ArticleACS synthetic biology2023

Predicting and Interpreting Protein Developability Via Transfer of Convolutional Sequence Representation.

Alexander W Golinski, Zachary D Schmitz, Gregory H Nielsen, Bryce Johnson, Diya Saha, Sandhya Appiah, Benjamin J Hackel, Stefano Martiniani

Open access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander W GolinskiDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Zachary D SchmitzDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Gregory H NielsenDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Bryce JohnsonDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Diya SahaDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Sandhya AppiahDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Benjamin J HackelDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0003-3561-9463
Stefano MartinianiDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
University of Minnesota · US

Funding

Engineering protein developabilityR01GM146372 · NIGMS · UNIVERSITY OF MINNESOTA · PI HACKEL, BENJAMIN · 2022 to 2025
$1.4M
Engineering Gp2 as a small ligand scaffoldR01EB023339 · NIBIB · UNIVERSITY OF MINNESOTA · PI HACKEL, BENJAMIN · 2017 to 2020
$1.3M
NIBIB NIH HHS R01 EB023339NIGMS NIH HHS R01 GM146372
6 · The paper itself

Abstract

Engineered proteins have emerged as novel diagnostics, therapeutics, and catalysts. Often, poor protein developability─quantified by expression, solubility, and stability─hinders utility. The ability to predict protein developability from amino acid sequence would reduce the experimental burden when selecting candidates. Recent advances in screening technologies enabled a high-throughput (HT) developability dataset for 10

Indexed as

Amino AcidsCysteineAmino Acid SequenceNeural Networks, ComputerProtein EngineeringAmino AcidsCysteinedevelopabilitylandscapemodelpredictiveproteinsequence

Identifiers

PMID37642646
PMCPMC10829850
OpenAlexW4386256749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.