ArticleCerebral cortex (New York, N.Y. : 1991)2023
A comparison of behavioral paradigms assessing spatial memory in tree shrews.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 1 citations in OpenAlex.
- Article
- An anatomical and connectivity atlas of the tree shrew brain to bridge rodent and primate neuroanatomy.PLoS biology · 2026Article
- Visual Motion Processing in The Tree Shrew Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Distributions of parvalbumin, calbindin-D28k, and calretinin in the cerebrum of Chinese tree shrews (Zoological research · 2025Article
- Study of tree shrew biology and models: A booming and prosperous field for biomedical research.Zoological research · 2024Review
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6 authors at 1 institution in 1 country.
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Abstract
Impairments in spatial navigation in humans can be preclinical signs of Alzheimer's disease. Therefore, cognitive tests that monitor deficits in spatial memory play a crucial role in evaluating animal models with early stage Alzheimer's disease. While Chinese tree shrews (Tupaia belangeri) possess many features suitable for Alzheimer's disease modeling, behavioral tests for assessing spatial cognition in this species are lacking. Here, we established reward-based paradigms using the radial-arm maze and cheeseboard maze for tree shrews, and tested spatial memory in a group of 12 adult males in both tasks, along with a control water maze test, before and after bilateral lesions to the hippocampus, the brain region essential for spatial navigation. Tree shrews memorized target positions during training, and task performance improved gradually until reaching a plateau in all 3 mazes. However, spatial learning was compromised post-lesion in the 2 newly developed tasks, whereas memory retrieval was impaired in the water maze task. These results indicate that the cheeseboard task effectively detects impairments in spatial memory and holds potential for monitoring progressive cognitive decline in aged or genetically modified tree shrews that develop Alzheimer's disease-like symptoms. This study may facilitate the utilization of tree shrew models in Alzheimer's disease research.
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