Evidence map›Paper›PMID 37642583›Full record

ArticleAutophagy2024

Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system.

Akshay Kapadia, Sandra Theil, Sabine Opitz, Nàdia Villacampa, Hannes Beckert, Susanne Schoch, Michael T Heneka, Sathish Kumar, Jochen Walter

Open access · hybridAbstract read
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Akshay KapadiaMolecular Cell Biology, Department of Neurology, University Hospital Bonn, Bonn, Germany.
Sandra TheilMolecular Cell Biology, Department of Neurology, University Hospital Bonn, Bonn, Germany.
Sabine OpitzNeuroinflammation Unit, German Center for Neurodegenerative Diseases e. V. (DZNE), Bonn, Germany.
Nàdia VillacampaNeuroinflammation Unit, German Center for Neurodegenerative Diseases e. V. (DZNE), Bonn, Germany.
Hannes BeckertMicroscopy core facility, University Hospital Bonn, Bonn, Germany.
Susanne SchochSection for Translational Epilepsy Research, Department of Neuropathology, University Hospital Bonn, Bonn, Germany.
Michael T HenekaNeuroinflammation Unit, German Center for Neurodegenerative Diseases e. V. (DZNE), Bonn, Germany.
Sathish KumarMolecular Cell Biology, Department of Neurology, University Hospital Bonn, Bonn, Germany.
Jochen WalterMolecular Cell Biology, Department of Neurology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-4678-2912
University Hospital Bonn · DEGerman Center for Neurodegenerative Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abbreviationsAD: Alzheimer disease; APP: amyloid beta precursor protein; ATG: autophagy related; Aβ: amyloid-β; CTSD: cathepsin D; DAPI: 4',6-diamidino-2-phenylindole; EEA1: early endosome antigen 1; FA: formic acid; GFP: green fluorescent protein; LAMP2: lysosomal-associated membrane protein 2; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAP2: microtubule-associated protein 2; nmAβ: non-modified amyloid-β; npAβ: non-phosphorylated amyloid-β; pAβ: phosphorylated amyloid-β; p-Ser26Aβ: amyloid-β phosphorylated at serine residue 26; p-Ser8Aβ: amyloid-β phosphorylated at serine residue 8; RAB: RAB, member RAS oncogene family; RFP: red fluorescent protein; SQSTM1/p62: sequestome 1; YFP: yellow fluorescent protein.

Indexed as

Amyloid beta-PeptidesAutophagyGreen Fluorescent ProteinsLysosomesPhosphorylationSerineAmyloid beta-PeptidesGreen Fluorescent ProteinsSerineAlzheimer’s diseaseautophagic fluxneurodegenerationphosphorylated Aβpost-translationally modified Aβvesicular trafficking

Identifiers

PMID37642583
PMCPMC10761119
OpenAlexW4386245279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.