ArticleJournal of the American Heart Association2023
Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Clinical obesity in Asian people: bridging the gap between adiposity and disease.Nature reviews. Endocrinology · 2026Review
- Integrative Analysis Uncover the Effects and Multi-Omics Features of Thigh Muscle Fat Infiltration.Aging cell · 2026Article
- Hypertrophic Effects of Single- versus Multi-Joint Exercise: A Direct Comparison between Knee Extension and Leg Press.Medicine and science in sports and exercise · 2026Article
- Association of fat-to-muscle mass ratio with incident coronary artery disease and the potential role of metabolic signatures.Cardiovascular diabetology · 2026Article
- Association of a novel Fat-Muscle-BMI Index (FMBI) with NAFLD, liver fibrosis, and atherosclerotic cardiovascular disease risk: a cross-sectional study in 1,592 Chinese adults.BMC gastroenterology · 2026Article
- Association of total and regional fat-to-muscle ratio with the risk of metabolic dysfunction-associated fatty liver disease and other chronic liver diseases.Hepatology international · 2026Article
- Device-Specific Sex- and Age-Stratified Distributions of Phase Angle and Skeletal Muscle Mass in a Routine Outpatient Multifrequency Bioelectrical Impedance Cohort.Obesity science & practice · 2026Article
- Muscle Mass Moderates Metabolic Syndrome Risk Associated with Adiposity: A SHAP-Based Machine Learning Study.Nutrients · 2026Article
- Insulin resistance and metabolic health predict cardiorespiratory fitness: cohort study.European heart journal open · 2026Article
- Association of mild cognitive impairment and obesity-metabolic status in middle-aged and elderly adults: a nationwide prospective cohort study.Journal of neurology · 2026Review
- Association between weight-adjusted waist index and risk of mortality and disease progression in participants with chronic kidney disease: a prospective study from the UK Biobank.Frontiers in nutrition · 2026Article
- Clinical and Preclinical Obesity in Korean Adults from 2014 to 2023.Diabetes & metabolism journal · 2026Article
- Body mass index, waist circumference and the association with all-cause and cause-specific mortality: a 7.2-year follow-up cohort study in Shanghai, China.BMC public health · 2025Article
- Body Muscle-to-Fat Ratio (BMFR) as a Promising Anthropometric Index for Use in the Evaluation of Insulin Resistance and Metabolic Disease Risk: a Narrative Review.Current obesity reports · 2025Review
- Observational
- Relationship Between Body Composition and Biomarkers in Adult Females with Breast Cancer: 1-Year Follow-Up Prospective Study.Nutrients · 2025Observational
- Diagnostic accuracy of various anthropometric indexes for assessing insulin resistance in the Peruvian population: An analytical cross-sectional study.Journal of public health research · 2025Article
- Total and regional fat-to-muscle mass ratio and risks of pan-cancer: a prospective cohort study.BMC medicine · 2025Article
- The Critical Role of Body Composition Assessment in Advancing Research and Clinical Health Risk Assessment across the Lifespan.Journal of obesity & metabolic syndrome · 2025Review
- Sex-specific Associations of Aldosterone and Renin With Body Composition: A Population-based Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background To evaluate the sex-specific associations of total and regional fat/muscle mass ratio (FMR) with cardiovascular disease (CVD) incidence and mortality, and to explore the underlying mechanisms driven by cardiometabolites and inflammatory cells. We compared the predictive value of FMRs to body mass index. Methods and Results This population-based, prospective cohort study included 468 885 UK Biobank participants free of CVD at baseline. Fat mass and muscle mass were estimated using a bioelectrical impedance assessment device. FMR was calculated as fat mass divided by muscle mass in corresponding body parts (total body, trunk, arm, and leg). Multivariable Cox proportional hazards models and mediation analyses were used. During 12.5 years of follow-up, we documented 49 936 CVD cases and 4158 CVD deaths. Higher total FMR was associated with an increased risk of incident CVD (hazard ratios [HRs] were 1.63 and 1.83 for men and women, respectively), ischemic heart disease (men: HR, 1.61; women: HR, 1.81), myocardial infarction (men: HR, 1.72; women: HR, 1.49), and congestive heart failure (men: HR, 2.25; women: HR, 2.57). The positive associations of FMRs with mortality from total CVD or its subtypes were significant mainly in trunk and arm for male patients (
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