Trial reportJournal of the American Heart Association2023
Long-Term Impact of Additional Ablation After Pulmonary Vein Isolation: Results From EARNEST-PVI Trial.
Trial report in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta analysis of pulmonary vein isolation compared with additional ablation strategies for atrial fibrillation.BMC cardiovascular disorders · 2025Pooled it
- Hemoglobin Levels as a Marker of Arrhythmia Recurrence After Atrial Fibrillation Ablation.Journal of arrhythmia · 2026Article
- Temporal dynamics of left atrial reverse remodeling predicts atrial fibrillation ablation outcome: A 3-year longitudinal study.Journal of geriatric cardiology : JGC · 2026Article
- Both Electrical Isolation and Lesion Homogeneity Should be Focused: Evidence From Repeat Atrial Fibrillation Ablation.Journal of cardiovascular electrophysiology · 2026Article
- Towards mechanisms-driven strategy for persistent atrial fibrillation ablation: Leveraging digital twins.Journal of precision medicine (Amsterdam, Netherlands) · 2026Article
- Automated generation of ablation lesion masks: a unison of electro and optic flow mapping for persistent AF virtual cohorts.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Pulsed-Field Ablation for Persistent Atrial Fibrillation in EU-PORIA Registry.Journal of cardiovascular electrophysiology · 2025Article
- Persistent atrial fibrillation ablation: glimpsing the light ahead?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- Clinical insights into the role of bepridil in recurrence prevention after ablation of persistent atrial fibrillation.Journal of arrhythmia · 2025Article
- Digital twins enable stratification of persistent atrial fibrillation patients for ablation diminishing unnecessary heart damage.NPJ digital medicine · 2025Article
- Does organized atrial tachycardia after a pulmonary vein isolation-only procedure portend better outcome of repeat ablation compared to recurrent atrial fibrillation?Journal of arrhythmia · 2025Article
- Electrophysiological Findings in Patients with Early Recurrence During Blanking Period Following Atrial Fibrillation Ablation.Anatolian journal of cardiology · 2025Article
- Integrated Management of Persistent Atrial Fibrillation.Biomedicines · 2025Review
- Chronic Effects of Vein of Marshall Ethanol Infusion on Pulmonary Vein and Mitral Isthmus Reconnection.Arrhythmia & electrophysiology review · 2025Article
- Bipolar catheter ablation of a left atrial anteroseptal line in a patient with peri-mitral atrial flutter: a case report.European heart journal. Case reports · 2024Article
- Repeat ablation of atrial fibrillation using electrogram dispersion to identify additional areas of mechanistic significance.Heart rhythm O2 · 2024Article
- Risk and Protective Factors of Recurrence after Catheter Ablation for Atrial Fibrillation.Reviews in cardiovascular medicine · 2024Review
- Ablation for Persistent Atrial Fibrillation: Is There a Light at the End of the Tunnel?Journal of the American Heart Association · 2023Article
- Catheter ablation of atrial fibrillation: time to look beyond iterative pulmonary vein isolation only and "one-size-fits-all" strategies.Indian pacing and electrophysiology journalReview
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background An optimal strategy for left atrial ablation in addition to pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (AF) has not been determined. Methods and Results We conducted an extended follow-up of the multicenter randomized controlled EARNEST-PVI (Efficacy of Pulmonary Vein Isolation Alone in Patients With Persistent Atrial Fibrillation) trial, which compared 12-month rhythm outcomes in patients with persistent AF between patients randomized to a PVI-alone strategy (n=248) or PVI-plus strategy (n=248; PVI followed by left atrial additional ablation, including linear ablation or ablation targeting areas with complex fractionated electrograms). The present study extended the follow-up period to 3 years after enrollment. Outcomes were compared not only between randomly allocated groups but also between on-treatment groups categorized by actually created ablation lesions. Recurrence rate of AF or atrial tachycardia (AT) was lower in the randomly allocated to PVI-plus group than the PVI-alone group (29.0% versus 37.5%,
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