Evidence map›Paper›PMID 37641872›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2023

Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity.

Tomáš Macháček, Claudia D Fuchs, Franziska Winkelmann, Marcus Frank, Hubert Scharnagl, Tatjana Stojakovic, Martina Sombetzki, Michael Trauner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. The avian schistosomeFood and waterborne parasitology · 2025
    Article
  2. Article
  3. Bsep/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity.Liver international : official journal of the International Association for the Study of the Liver · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Tomáš MacháčekDivision of Tropical Medicine and Infectious Diseases, Center of Internal Medicine II, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0002-6310-4099
Claudia D FuchsHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-0636-1320
Franziska WinkelmannDivision of Tropical Medicine and Infectious Diseases, Center of Internal Medicine II, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0003-0248-8751
Marcus FrankMedical Biology and Electron Microscopy Center, University Medical Center Rostock, Rostock, Germany.ORCID 0000-0002-2517-4440
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.ORCID 0000-0002-2750-006X
Tatjana StojakovicClinical Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Graz, Graz, Austria.
Martina SombetzkiDivision of Tropical Medicine and Infectious Diseases, Center of Internal Medicine II, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0002-3861-0635
Michael TraunerHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1275-6425
University of Rostock · DEMedical University of Vienna · ATCharles University · CZMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSchistosoma mansoni infection is one of the worldwide leading causes of liver fibrosis and portal hypertension. The objective of this study was to evaluate whether polyhydroxylated bile acids (BAs), known to protect mice from the development of acquired cholestatic liver injury, counteract S. mansoni-induced inflammation and fibrosis.

methodsAdult FVB/N wild type (WT) and Abcb11/Bsep

resultsBsep

conclusionsThe loss of Bsep and the resulting changes in bile acid composition and blood pH are associated with the reduction of parasite fecundity, thus attenuating the development of S. mansoni-induced hepatic inflammation and fibrosis.

Indexed as

ParasitesSchistosomiasis mansoniAnimalsATP Binding Cassette Transporter, Subfamily B, Member 11Bile Acids and SaltsCytokinesFertilityInflammationLiverLiver CirrhosisMiceSchistosoma mansoniAbcb11 protein, mouseATP Binding Cassette Transporter, Subfamily B, Member 11Bile Acids and SaltsCytokinesanti-inflammatorybile acidsinfectionliver fibrosisSchistosoma mansoni

Identifiers

PMID37641872
PMCPMC10947390
OpenAlexW4386245885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.