ArticleEarly intervention in psychiatry2024
Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS.
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Article in Early intervention in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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36 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis.Schizophrenia bulletin open · 2026Article
- Emergence and Dynamics of Delusions and Hallucinations Across Stages in Early Psychosis.Biological psychiatry · 2025Article
- Development and Validation of a Brief Age-Normed Screening Tool for Subthreshold Psychosis Symptoms in Youth.Schizophrenia bulletin · 2025Article
- Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms.Translational psychiatry · 2025Article
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Corrections and comments
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Authors and funding
73 authors.
Scott W WoodsDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-3103-5228
Sophie ParkerDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, Manchester, UK.
Melissa J KerrOrygen, Parkville, Victoria, Australia.
Barbara C WalshDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
S Andrea WijtenburgDivision of Translational Research, National Institute of Mental Health, Bethesda, Maryland, USA.
Nicholas PrunierDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Angela R NunezDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Kate BuccilliOrygen, Parkville, Victoria, Australia.
Catalina Mourgues-CodernDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Kali BrummittDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Kyle S KinneyDepartment of Psychology & Neuroscience, Temple University, Philadelphia, Pennsylvania, USA.
Carli TranklerDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Julia SzaciloCAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Beau-Luke ColtonDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, Manchester, UK.
Munaza AliDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Anastasia HaidarDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Tashrif BillahDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Kevin HuynhOrygen, Parkville, Victoria, Australia.
Uzair AhmedOrygen, Parkville, Victoria, Australia.
Laura L AderyDepartments of Psychiatry and Biobehavioral Sciences & Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.ORCID 0000-0003-0659-8309
Patricia J MarcyFeinstein Institute for Medical Research, Manhasset, New York, USA.
Kelly AllottOrygen, Parkville, Victoria, Australia.ORCID 0000-0002-0640-4634
Paul AmmingerOrygen, Parkville, Victoria, Australia.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.
Matthew R BroomeInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Kristin S CadenheadDepartment of Psychiatry, University of California, San Diego, California, USA.
Eric Y H ChenDepartment of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.ORCID 0000-0002-5247-3593
Jimmy ChoiOlin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health Network, Hartford, Connecticut, USA.
Philippe ConusChef de Service Service de Psychiatrie Générale Dép. de Psychiatrie CHUV Lausanne, Lausanne, Switzerland.
Barbara A CornblattFeinstein Institute for Medical Research, Manhasset, New York, USA.
Louise Birkedal GlenthøjCopenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3621-8450
Leslie E HortonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Joseph KambeitzFaculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Tina KapurBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Matcheri S KeshavanBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Nikolaos KoutsoulerisDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany.
Kerstin LangbeinDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Suzie LavoieOrygen, Parkville, Victoria, Australia.ORCID 0000-0001-8372-2399
Covadonga Martinez Diaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain.ORCID 0000-0001-8538-3175
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Vijay A MittalDepartment of Psychology, Northwestern University, Chicago, Illinois, USA.
Merete NordentoftMental Health Services in the Capital Region, Copenhagen, Denmark.
Ofer PasternakBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Godfrey D PearlsonDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Pablo A GasparDepartment of Psychiatry, IMHAY, University of Chile, Santiago, Chile.ORCID 0000-0002-9682-5327
Jai L ShahPEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada.
Stefan SmesnyDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
William S StoneBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-7218-5169
Jijun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Cheryl M CorcoranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
Jason SchiffmanDepartment of Psychological Science, University of California, Irvine, California, USA.
Jesus PerezCAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Daniel MamahDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Lauren M EllmanDepartment of Psychology & Neuroscience, Temple University, Philadelphia, Pennsylvania, USA.
Albert R PowersDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Michael J ColemanDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Alan AnticevicDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Paolo Fusar-PoliDepartment of Psychosis Studies, King's College London, London, UK.ORCID 0000-0003-3582-6788
John M KaneFeinstein Institute for Medical Research, Manhasset, New York, USA.
Rene S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Patrick D McGorryOrygen, Parkville, Victoria, Australia.
Carrie E BeardenDepartments of Psychiatry and Biobehavioral Sciences & Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
Martha E ShentonDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4235-7879
Barnaby NelsonOrygen, Parkville, Victoria, Australia.
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0546-0263
Larry HendricksOrygen, Parkville, Victoria, Australia.
Sylvain BouixDepartment of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-8298-0756
Thomas H McGlashanDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Alison R YungDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, Manchester, UK.
Accelerating Medicines Partnership Schizophrenia
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2MPsychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination CenterU24MH124629 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Rene S. Kahn, Martha E. Shenton · 2020 to 2026
$32.6MTrajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)U01MH124631 · NIMH · UNIVERSITY OF MELBOURNE · PI Christopher Barnaby Nelson · 2020 to 2026
$30.4MPreclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7MNeurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9MBrain connectivity and the role of myelin in PsychosisR01MH113619 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRANGOU, SOPHIA · 2018 to 2021
$2.5MNCATS NIH HHS UL1 TR001863NICHD NIH HHS P50 HD103573NIMH NIH HHS R01 MH113619NIMH NIH HHS R37 MH085953NIMH NIH HHS U01 MH124631NIMH NIH HHS U01 MH124639NIMH NIH HHS U24 MH124629Wellcome TrustWellcome Trust 220664/A/20/ZWellcome Trust 220664/Z/20/Z
Abstract
aimTo harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental States (CAARMS).
methodsThe initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR-P through an intensive series of joint videoconferences.
resultsFull harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR-P criteria. The semi-structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR-P criteria and severity scores for both CAARMS and SIPS.
conclusionsUsing the PSYCHS for CHR-P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta-analyses.
Indexed as
Psychotic DisordersHumansProdromal SymptomsPsychiatric Status Rating Scalesascertainmentclinical high riskearly detectionpsychometricsseverity rating
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