ArticleGenome biology2023
A high-resolution genotype-phenotype map identifies the TaSPL17 controlling grain number and size in wheat.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Pangenome-resolved structural variation drives adaptation and trait evolution in cucumber.Nature genetics · 2026Article
- Regulation of spikelet number during wheat spike development.bioRxiv : the preprint server for biology · 2026Article
- O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering.Nature communications · 2025Article
- Antagonistic effects of selection on alleles associated with seed size and seed dormancy in wheat.Genome biology · 2025Article
- Large-scale identification and association analysis of wheat grain weight genes using rice orthologs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- k-mer-based GWAS in a wheat collection reveals novel and diverse sources of powdery mildew resistance.Genome biology · 2025Article
- Article
- Single- and multi-locus genome-wide association study reveals genomic regions of thirteen yield-related traits in common wheat.BMC plant biology · 2024Article
- CSGDN: contrastive signed graph diffusion network for predicting crop gene-phenotype associations.Briefings in bioinformatics · 2024Article
- LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat.Development (Cambridge, England) · 2024Article
- Article
- A diverse panel of 755 bread wheat accessions harbors untapped genetic diversity in landraces and reveals novel genetic regions conferring powdery mildew resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Efficient identification of QTL for agronomic traits in foxtail millet (Setaria italica) using RTM- and MLM-GWAS.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- The Class III Peroxidase geneFrontiers in plant science · 2024Article
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLarge-scale genotype-phenotype association studies of crop germplasm are important for identifying alleles associated with favorable traits. The limited number of single-nucleotide polymorphisms (SNPs) in most wheat genome-wide association studies (GWASs) restricts their power to detect marker-trait associations. Additionally, only a few genes regulating grain number per spikelet have been reported due to sensitivity of this trait to variable environments.
resultsWe perform a large-scale GWAS using approximately 40 million filtered SNPs for 27 spike morphology traits. We detect 132,086 significant marker-trait associations and the associated SNP markers are located within 590 associated peaks. We detect additional and stronger peaks by dividing spike morphology into sub-traits relative to GWAS results of spike morphology traits. We propose that the genetic dissection of spike morphology is a powerful strategy to detect signals for grain yield traits in wheat. The GWAS results reveal that TaSPL17 positively controls grain size and number by regulating spikelet and floret meristem development, which in turn leads to enhanced grain yield per plant. The haplotypes at TaSPL17 indicate geographical differentiation, domestication effects, and breeding selection.
conclusionOur study provides valuable resources for genetic improvement of spike morphology and a fast-forward genetic solution for candidate gene detection and cloning in wheat.
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