ArticleParticle and fibre toxicology2023
Long-term exposure to polystyrene microplastics triggers premature testicular aging.
Article in Particle and fibre toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Micro- and nanoplastics in the human genitourinary system: oncological impact - a systematic review.BJU international · 2026Pooled it
- Targeting Modifiable Risks: Molecular Mechanisms and Population Burden of Lifestyle Factors on Male Genitourinary Health.International journal of molecular sciences · 2025Pooled it
- Systematic review of potential developmental and reproductive toxicity of microplastics.Toxicological sciences : an official journal of the Society of Toxicology · 2025Pooled it
- Irisin and Exercise Ameliorate the Polyethylene Microplastics-Induced Blood-Testis Barrier Disruption via PGC-1α Activation and AMPK/Nrf2/HO-1 Signaling.Journal of applied toxicology : JAT · 2026Article
- Mechanisms of Polystyrene Microplastics in Multipathway Disruption of the Blood-Testis Barrier.Andrology · 2026Article
- Effects of micro- and nano-plastics exposure on cellular senescence: an overview.Archives of toxicology · 2026Review
- Microplastics and male reproductive system: A comprehensive review based on cellular and molecular effects.Toxicology reports · 2026Review
- Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives.Archives of toxicology · 2026Review
- Pollutant-regulated mitophagy: new perspectives in environmental toxicology.Apoptosis : an international journal on programmed cell death · 2026Review
- Microplastic exposure and human health risks across the life cycle: a focus on reproduction, development, and aging.Frontiers in cell and developmental biology · 2026Review
- Polystyrene-associated pulmonary fibrosis: a summary based on the available evidence and prospects.Frontiers in immunology · 2026Review
- Microplastic-induced multi-organ toxicity: cellular mechanisms and critical roles of organ crosstalk.Frontiers in public health · 2026Review
- From exposure to oncogenesis: a review on the multifaceted roles of microplastics in tumor initiation and progression.Journal of translational medicine · 2025Review
- The Threat of Micro-/Nanoplastics to Male Fertility: A Review of the Data and the Importance of Future Research.International journal of molecular sciences · 2025Review
- Melatonin Alleviates the Damage of Polystyrene Microplastics to Porcine Oocytes by Reducing Oxidative Stress and Mitochondrial Damage, and Regulating Autophagy and Apoptosis Levels.Animals : an open access journal from MDPI · 2025Article
- Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects.Toxics · 2025Review
- Multi-omics analysis of testis after long-term exposure to polystyrene nanoplastics reveals premature testicular aging and age-dependent damage in mice.Particle and fibre toxicology · 2025Article
- Polystyrene Accelerates Aging Related-Gut Microbiome Dysbiosis and -Metabolites in Old-Aged Mouse.Journal of microbiology and biotechnology · 2025Article
- Article
- Forever particles: histochemistry in the plasticene age.European journal of histochemistry : EJH · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlastic pollution is greatly serious in the ocean and soil. Microplastics (MPs) degraded from plastic has threatened animals and humans health. The accumulation of MPs in the tissues and blood in animals and humans has been found. There is therefore a need to assess the toxicological effects of MPs on the reproductive system.
resultsIn this study, we explored the effect of polystyrene microplastics (PS-MPs) on premature testicular aging in vitro and in vivo. In vitro, we found that testicular sertoli cells (TM4 cells) was prematurely senescent following PS-MPs treatment by the evaluation of a range of aging marker molecules (such as Sa-β-gal, p16 and 21). TM4 cells were then employed for in vitro model to study the potential molecular mechanism by which PS-MPs induce the premature senescence of TM4 cells. NF-κB is identified as a key molecule for PS-MPs-induced TM4 cellular senescence. Furthermore, through eliminating reactive oxygen species (ROS), the activation of nuclear factor kappa B (NF-κB) was blocked in PS-MPs-induced senescent TM4 cells, indicating that ROS triggers NF-κB activation. Next, we analyzed the causes of mitochondrial ROS (mtROS) accumulation induced by PS-MPs, and results showed that Ca
conclusionIn short, our experimental results revealed that PS-MPs-caused testicular premature aging is dependent on Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.