Evidence map›Paper›PMID 37641018›Full record

ArticleBMC public health2023

Perspectives on long-acting formulations of pre-exposure prophylaxis (PrEP) among men who have sex with men who are non-adherent to daily oral PrEP in the United States.

Brooke G Rogers, P A Chan, C Sutten-Coats, A Zanowick-Marr, R R Patel, L Mena, W C Goedel, C Chu, E Silva, D Galipeau and 7 more

Open access · goldAbstract read
In one paragraph

Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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  12. Exploring Willingness to Use Long-Acting Injectable PrEP Among Sexual and Gender Minoritized People Accessing Pharmacies.AIDS education and prevention : official publication of the International Society for AIDS Education · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Brooke G RogersDepartment of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, Providence, 02903, USA. brooke_rogers@brown.edu.
P A ChanDepartment of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, Providence, 02903, USA.
C Sutten-CoatsDepartment of Social and Behavioral Sciences, Brown University School of Public Health, Rhode Island, Providence, 02903, USA.
A Zanowick-MarrDepartment of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, Providence, 02903, USA.
R R PatelDepartment of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA.
L MenaDepartment of Population Health Science, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
W C GoedelDepartment of Epidemiology, Brown University School of Public Health, Rhode Island, Providence, 02903, USA.
C ChuDepartment of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, Providence, 02903, USA.
E SilvaDepartment of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, Providence, 02903, USA.
D GalipeauDepartment of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, Providence, 02903, USA.
T ArnoldDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, 02903, USA.
C GomilliaDepartment of Medicine, Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
K CuroeDepartment of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA.
J VillalobosDepartment of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA.
A UnderwoodDepartment of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA.
C SosnowyDepartment of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, Providence, 02903, USA.
Amy S NunnDepartment of Medicine, Division of Infectious Diseases,, Warren Alpert Medical School of Brown University, Providence, 02903, USA. amy_nunn@brown.edu.
Brown University · USWashington University in St. Louis · USUniversity of Mississippi Medical Center · US

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
Characterizing the HIV pre-exposure prophylaxis care continuum for African American and Hispanic/Latino men who have sex with menR01MH114657 · NIMH · MIRIAM HOSPITAL · PI CHAN, PHILIP ANDREW, NUNN, AMY STEWART · 2017 to 2021
$3.4M
Improving HIV Prevention Through a Psychological Flexibility-Based ApproachK23MH124539 · NIMH · RHODE ISLAND HOSPITAL · PI ARNOLD, TRISHA · 2021 to 2025
$969k
NIAID NIH HHS P30 AI042853NIMH NIH HHS 5R01MH114657-02NIMH NIH HHS K23 MH124539NIMH NIH HHS K23MH124539-01A1NIMH NIH HHS L30 MH123946NIMH NIH HHS R01 MH114657NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

introductionPre-exposure prophylaxis (PrEP) persistence among men who have sex with men (MSM) in real world clinical settings for HIV prevention is suboptimal. New longer-acting formulations of PrEP are becoming available, including injectables, subdermal implants, and other oral medications. These longer-acting formulations have the potential to improve retention among those who have challenges remaining adherent to daily oral PrEP.

methodsWe interviewed 49 MSM who had initiated but discontinued oral PrEP at three diverse clinics across the United States. We examined participants' perspectives about long-acting PrEP formulations and how long-acting options could affect PrEP use using thematic analysis.

resultsParticipants were not very knowledgeable about long-acting formulations of PrEP but were open to learning about them and considering use. Participants were concerned about safety and efficacy of products given that they were still newer and/or in development. Finally, participants had clear preferences for oral pills, injectables, and then subdermal implants and were most interested in options that reduced the number of visits to the clinic.

conclusionLong-acting formulations of PrEP are acceptable to MSM with suboptimal PrEP persistence and have the potential to improve PrEP persistence. However, many felt they needed more information on safety, efficacy, and use to consider these options. As these long-acting formulations are implemented, public health campaigns and clinical interventions to encourage may maximize uptake particularly among those who are not currently adherent to daily oral PrEP.

Indexed as

Pre-Exposure ProphylaxisSexual and Gender MinoritiesAmbulatory Care FacilitiesEmotionsHomosexuality, MaleHumansMaleUnited StatesHIV preventionMedication adherenceMen who have sex with men (MSM)Pre-exposure prophylaxis (PrEP)PrEP continuum

Identifiers

PMID37641018
PMCPMC10463714
OpenAlexW4386222325

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.