Trial reportNature medicine2023
Natriuresis-guided diuretic therapy in acute heart failure: a pragmatic randomized trial.
Trial report in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06203236 (Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease), which is not on this map. Cited by 71 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease
Who cites it
71 citing papers in PubMed, 4 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Diuretic strategies in acute heart failure: a systematic review and network meta-analysis of randomized clinical trials.European heart journal. Cardiovascular pharmacotherapy · 2026Pooled it
- Urine sodium-guided diuresis in acute heart failure: a systematic review and meta-analysis of efficacy and safety.Heart failure reviews · 2025Pooled it
- Protocolized natriuresis-guided diuretic therapy in acute heart failure: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Systematic Review on the Management of Diuretic Resistance in Acute Heart Failure across the Spectrum of Kidney Disease.Cardiorenal medicine · 2025Pooled it
- Clinical profiles and prognostic impact of residual intravascular and tissue congestion in acute heart failure.European journal of heart failure · 2025Trial
- Diuretic resistance and the efficacy of hydrochlorothiazide in acute decompensated heart failure: A post-hoc analysis of the CLOROTIC trial.European journal of heart failure · 2025Trial
- Outpatient loop diuretic use and the effect of natriuresis-guided diuretic therapy: A prespecified sub-analysis of the PUSH-AHF study.European journal of heart failure · 2025Trial
- A Randomized Controlled Trial of Thoracentesis in Acute Heart Failure.Circulation · 2025Trial
- Torsemide Versus Furosemide After Discharge in Patients Hospitalized With Heart Failure Across the Spectrum of Ejection Fraction: Findings From TRANSFORM-HF.Circulation. Heart failure · 2024Trial
- Clinical significance of urinary sodium measurement for predicting pulmonary decongestion: a prospective observational study.Heart and vessels · 2026Article
- Effects of natriuresis-guided diuretic therapy in men and women with acute heart failure: insights from PUSH-AHF.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Personalized Sequential Nephron Blockade for Diuretic Resistance in Acute Decompensated Heart Failure: A Narrative Review for the Cardiorenal Clinician.Journal of personalized medicine · 2026Review
- The 'Chloride Theory' for Heart Failure Pathophysiology: An Updated Narrative Review 2025.Cardiology and therapy · 2026Review
- A machine-learning model for accurate diuresis prediction in acute heart failure (DRC-AHF).ESC heart failure · 2026Article
- Integrating Urinary Sodium into the Larissa Heart Failure Risk Score Improves Early Risk Stratification in Acute Heart Failure.Journal of cardiovascular development and disease · 2026Article
- Diuretics in Cardiovascular Disease: For How Long and at What Dose?Journal of cardiovascular development and disease · 2026Review
- The role of biomarkers across the care continuum in acute heart failure.Biomarker research · 2026Review
- Urinary Biomarkers for the Risk Assessment and Management of Heart Failure: Pearls and Pitfalls.Current heart failure reports · 2026Review
- Utility of urinary sodium to guide diuresis in acute decompensated heart failure.ESC heart failure · 2026Article
- Targeting oxidative stress, senescence, and neurodegeneration: anti-aging perspectives of Urtica dioica and Centella asiatica.Inflammopharmacology · 2026Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Measurement of natriuresis has been suggested as a reliable, easily obtainable biomarker for assessment of the response to diuretic treatment in patients with acute heart failure (AHF). Here, to assess whether natriuresis-guided diuretic therapy in patients with AHF improves natriuresis and clinical outcomes, we conducted the pragmatic, open-label Pragmatic Urinary Sodium-based algoritHm in Acute Heart Failure trial, in which 310 patients (45% female) with AHF requiring treatment with intravenous loop diuretics were randomly assigned to natriuresis-guided therapy or standard of care (SOC). In the natriuresis-guided arm, natriuresis was determined at set timepoints, prompting treatment intensification if spot urinary sodium levels were <70 mmol l
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.