Evidence map›Paper›PMID 37640689›Full record

ArticleAngewandte Chemie (International ed. in English)2023

An S=1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation.

Jared C Paris, Sha Hu, Aiwen Wen, Andrew C Weitz, Ronghai Cheng, Leland B Gee, Yijie Tang, Hyomin Kim, Arturo Vegas, Wei-Chen Chang and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Mechanism of OACS central science · 2025
    Article
  4. A 5,000-fold increase in the HAT reactivity of a nonheme FeProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. 10-Fold Increase in Hydrogen Atom Transfer Reactivity for a Series ofJournal of the American Chemical Society · 2025
    Article
  6. New Frontiers in Nonheme Enzymatic Oxyferryl Species.Chembiochem : a European journal of chemical biology · 2024
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jared C ParisDepartment of Chemistry, Carnegie Mellon University, 4400 Fifth Ave., Pittsburgh, PA 15213, USA.ORCID 0000-0001-9932-5208
Sha HuDepartment of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
Aiwen WenDepartment of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
Andrew C WeitzDepartment of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.ORCID 0000-0002-9001-1103
Ronghai ChengDepartment of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
Leland B GeeLCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Rd., Menlo Park, CA 94025, USA.ORCID 0000-0002-5817-3997
Yijie TangDepartment of Chemistry, Carnegie Mellon University, 4400 Fifth Ave., Pittsburgh, PA 15213, USA.ORCID 0000-0003-2628-6230
Hyomin KimDepartment of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
Arturo VegasDepartment of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
Wei-Chen ChangDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0002-2341-9846
Sean J ElliottDepartment of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.ORCID 0000-0003-0096-9551
Pinghua LiuDepartment of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.ORCID 0000-0002-9768-559X
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, 4400 Fifth Ave., Pittsburgh, PA 15213, USA.ORCID 0000-0002-4132-3565
Boston University · USCarnegie Mellon University · USNorth Carolina State University · USSLAC National Accelerator Laboratory · US

Funding

Understanding How Nonheme Iron-Dependent Enzymes Assemble Pharmacophores: Studies of Cyclopropane, Aziridine, and Isonitrile FormationR01GM127588 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Wei-chen Chang · 2018 to 2026
$3.3M
Redox Cofactor Diversity in Enzymatic SuperfamiliesR35GM136294 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SEAN J ELLIOTT · 2020 to 2026
$2.9M
Alkaloid Biosynthetic StudiesR01GM140040 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LIU, PINGHUA · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM127588NIGMS NIH HHS R01 GM140040NIGMS NIH HHS R35 GM136294
6 · The paper itself

Abstract

Ergothioneine (ESH) and ovothiol A (OSHA) are two natural thiol-histidine derivatives. ESH has been implicated as a longevity vitamin and OSHA inhibits the proliferation of hepatocarcinoma. The key biosynthetic step of ESH and OSHA in the aerobic pathways is the O

Indexed as

HistidineIronCatalysisLigandsOxidative Stressferryl ironHistidineIronLigandsErgothioneineFerryl IntermediatesHigh-Valent IronOvothiol AOxidative C−S Bond Formation

Identifiers

PMID37640689
PMCPMC10592081
OpenAlexW4386210077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.