Evidence map›Paper›PMID 37640687›Full record

ArticleAddiction (Abingdon, England)2023

Changes to opioid overdose deaths and community naloxone access among Black, Hispanic and White people from 2016 to 2021 with the onset of the COVID-19 pandemic: An interrupted time-series analysis in Massachusetts, USA.

Xiao Zang, Alexander Y Walley, Avik Chatterjee, Simeon D Kimmel, Jake R Morgan, Sean M Murphy, Benjamin P Linas, Shayla Nolen, Brittni Reilly, Catherine Urquhart and 2 more

Open access · greenAbstract read
In one paragraph

Article in Addiction (Abingdon, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Xiao ZangDepartment of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
Alexander Y WalleyDepartment of Medicine, Section of General Internal Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.ORCID 0000-0002-8158-4882
Avik ChatterjeeDepartment of Medicine, Section of General Internal Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.
Simeon D KimmelDepartment of Medicine, Section of General Internal Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.
Jake R MorganDepartment of Health Law, Policy and Management, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-1559-3983
Sean M MurphyDepartment of Population Health Sciences, Weill Cornell Medical College, New York City, NY, USA.ORCID 0000-0001-9104-0670
Benjamin P LinasSection of Infectious Diseases, Boston Medical Center, Boston, MA, USA.ORCID 0000-0001-9574-7075
Shayla NolenDepartment of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
Brittni ReillyMassachusetts Department of Public Health, Boston, MA, USA.
Catherine UrquhartMassachusetts Department of Public Health, Boston, MA, USA.
Bruce R SchackmanDepartment of Population Health Sciences, Weill Cornell Medical College, New York City, NY, USA.ORCID 0000-0002-1132-2932
Brandon D L MarshallDepartment of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.ORCID 0000-0002-0134-7052
Boston University · USBrown University · USCornell University · USMassachusetts Department of Public Health · USUniversity of Minnesota · US

Funding

Utilization of health services after engagement with opioid use disorder (OUD) treatment provider by individuals with and without post-traumatic stress disorderP30DA040500 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Yuhua Bao · 2015 to 2026
$20.7M
DAT-18-06 Prevention and Rescue Of Fentanyl and Other Opioid Overdoses Using Optimized Naloxone Distribution Strategies (PROFOUND)U01DA047408 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARSHALL, BRANDON DAVID LEWIS, SCHACKMAN, BRUCE R · 2019 to 2023
$3.5M
Improving Naloxone Access and Its Effects on Drug Abuse and OverdosesR01CE002999 · CE · RAND CORPORATION · PI POWELL, DAVID · 2018 to 2020
$1.9M
ACL HHS R01CE002999NCIPC CDC HHS R01 CE002999NIDA NIH HHS P30 DA040500NIDA NIH HHS U01 DA047408
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe onset of the coronavirus disease 2019 (COVID-19) pandemic was associated with a surge in opioid overdose deaths in Massachusetts, particularly affecting racial and ethnic minority communities. We aimed to compare the impact of the pandemic on opioid overdose fatalities and naloxone distribution from community-based programs across racial and ethnic groups in Massachusetts.

designInterrupted time-series. SETTING AND CASES: Opioid overdose deaths (OODs) among non-Hispanic White, non-Hispanic Black, Hispanic and non-Hispanic other race people in Massachusetts, USA (January 2016 to June 2021). MEASUREMENTS: Rate of OODs per 100 000 people, rate of naloxone kits distributed per 100 000 people and ratio of naloxone kits per opioid overdose death as a measure of naloxone availability. We applied five imputation strategies using complete data in different periods to account for missingness of race and ethnicity for naloxone data.

findingsBefore COVID-19 (January 2016 to February 2020), the rate of OODs declined among non-Hispanic White people [0.2% monthly reduction (95% confidence interval = 0.0-0.4%)], yet was relatively constant among all other population groups. The rate of naloxone kits increased across all groups (0.8-1.2% monthly increase) and the ratio of naloxone kits per OOD death among non-Hispanic White was 1.1% (0.8-1.4%) and among Hispanic people was 1.0% (0.2-1.8%). After the onset of the pandemic (March 2020+), non-Hispanic Black people experienced an immediate increase in the rate of OODs [63.6% (16.4-130%)], whereas rates among other groups remained similar. Trends in naloxone rescue kit distribution did not substantively change among any groups, and the ratio of naloxone kits per OOD death for non-Hispanic Black people did not compensate for the surge in OODs deaths in this group.

conclusionsWith the onset of the COVID-19 pandemic, there was a surge in opioid overdose deaths among non-Hispanic Black people in Massachusetts, USA with no compensatory increase in naloxone rescue kit distribution. For non-Hispanic White and Hispanic people, opioid overdose deaths remained stable and naloxone kit distribution continued to increase.

Indexed as

COVID-19NaloxoneOpiate OverdoseAnalgesics, OpioidBlack or African AmericanBlack PeopleEthnicityHispanic or LatinoHumansInterrupted Time Series AnalysisMassachusettsMinority GroupsPandemicsWhiteAnalgesics, OpioidNaloxoneCOVID-19interrupted time-seriesMassachusettsnaloxone availabilityopioid overdose deathsracial and ethnic disparities

Identifiers

PMID37640687
PMCPMC10986189
OpenAlexW4386210116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.