Evidence map›Paper›PMID 37640446›Full record

ReviewInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society2023

Evolving treatment paradigms in metastatic or recurrent low-grade endometrial cancer: When is hormonal-based therapy the preferred option?

Haider Mahdi, Isabelle Ray-Coquard, Domenica Lorusso, Mansoor Raza Mirza, Bradley J Monk, Brian Slomovitz

Open access · hybridAbstract readReview
In one paragraph

Review in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  6. Frontiers in oncology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Haider MahdiDepartment of Obstetrics and Gynecology, Women's Health Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Isabelle Ray-CoquardGroupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire (GINECO), Centre Leon Berard, Lyon, Rhône-Alpes, France.ORCID 0000-0003-2472-8306
Domenica LorussoFondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Mansoor Raza MirzaDepartment of Oncology, Rigshospitalet, Kobenhavn, Denmark.
Bradley J MonkHonorHealth Research Institute, University of Arizona, Creighton University, Phoenix, Arizona, USA.ORCID 0000-0001-6985-0159
Brian SlomovitzDivision of Gynecologic Oncology, Mount Sinai Medical Center, Miami Beach, Florida, USA bslomovitz@gog.org.ORCID 0000-0002-7241-3096
Centre Léon Bérard · FRCleveland Clinic · USCreighton University · USMount Sinai Medical Center · USRigshospitalet · DKUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial cancer is the most common gynecologic malignancy in developed countries, with increasing incidence and mortality rates worldwide. While most cases are successfully treated with surgery, first-line treatment options for metastatic or recurrent endometrial cancer involve significant toxicities. Imprecise classification of heterogeneous subgroups further complicates treatment decisions and interpretation of clinical trial results. Recent advances in molecular classification are guiding treatment decisions for metastatic or recurrent endometrial cancers. Integrating molecular characteristics with traditional clinicopathology can both reduce overtreatment or undertreatment and help guide the appropriate choice of therapies and effective design of future studies. Here we discuss the treatment of metastatic or recurrent low-grade endometrioid adenocarcinoma of the uterine corpus, which is distinct from high-grade tumors histologically, molecularly, and in treatment response.

Indexed as

Carcinoma, EndometrioidEndometrial NeoplasmsFemaleHumansNeoplasm Recurrence, LocalEndometrium

Identifiers

PMID37640446
PMCPMC10646884
OpenAlexW4386222312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.