Evidence map›Paper›PMID 37640051›Full record

ArticleAmerican journal of perinatology2024

Glycated Albumin and Glycemia in Pregnancy and Postpartum: A Pilot Study.

Marti D Soffer, Kaitlyn E James, Tanayott Thaweethai, Michael Callahan, William H Barth, Camille E Powe

Open access · greenAbstract read
In one paragraph

Article in American journal of perinatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Marti D SofferHarvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9066-9757
Kaitlyn E JamesHarvard Medical School, Boston, Massachusetts.
Tanayott ThaweethaiHarvard Medical School, Boston, Massachusetts.
Michael CallahanDiabetes Unit, Massachusetts General Hospital, Boston, Massachusetts.
William H BarthHarvard Medical School, Boston, Massachusetts.
Camille E PoweHarvard Medical School, Boston, Massachusetts.
Harvard University · USBroad Institute · USMassachusetts General Hospital · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Elucidating Determinants of Gestational Beta-Cell Adaptation and FailureK23DK113218 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI POWE, CAMILLE ELISE · 2017 to 2021
$1.0M
NCATS NIH HHS UL1 TR002541NIDDK NIH HHS K23 DK113218
6 · The paper itself

Abstract

objectivePercent glycated albumin (%GAlb) is a marker of glycemia over the past 2 to 3 weeks in nonpregnant individuals. Longitudinal changes in %GAlb extending throughout pregnancy and postpartum (PP) have not been described. We aimed to describe levels of %GAlb throughout pregnancy and PP and relationships with glycemia. STUDY

designFifty women among those in the Study of Pregnancy Regulation of INsulin and Glucose cohort underwent 75-g oral glucose tolerance tests (OGTTs) at a mean of 13 weeks (V1) and 26 weeks (V2) of gestation and 11 weeks' PP. %GAlb was measured on frozen plasma samples.

resultsTotal albumin decreased from V1 to V2 and increased PP to levels higher than at V1. %GAlb declined between V1 and V2 (

conclusion%GAlb decreases between early and late gestation and remains decreased PP, despite a PP increase in total albumin above early pregnancy values. Given the lack of correlation with OGTT values or A1c, %GAlb is unlikely to be useful in assessing glycemia in pregnant or PP women. KEY POINTS: · Changes in %GAlb extending to the postpartum period have not been described.. · %GAlb decreases in pregnancy and remains decreased postpartum, despite a postpartum increase in total albumin above early pregnancy values.. · Glycemia measurements nor A1c were associated with %GAlb at any time point, therefore, %GAlb is unlikely to be useful in assessing glycemia in pregnant or postpartum women..

Indexed as

Diabetes, GestationalSerum AlbuminBlood GlucoseFemaleGlucose Tolerance TestGlycated HemoglobinHumansPilot ProjectsPostpartum PeriodPregnancyBlood GlucoseGlycated HemoglobinSerum Albumin

Identifiers

PMID37640051
PMCPMC11412737
OpenAlexW4386213255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.