Evidence map›Paper›PMID 37639629›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2023

Federated and distributed learning applications for electronic health records and structured medical data: a scoping review.

Siqi Li, Pinyan Liu, Gustavo G Nascimento, Xinru Wang, Fabio Renato Manzolli Leite, Bibhas Chakraborty, Chuan Hong, Yilin Ning, Feng Xie, Zhen Ling Teo and 5 more

Abstract readScoping Review
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Large Language Models in Lung Cancer: Systematic Review.Journal of medical Internet research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Siqi LiCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.
Pinyan LiuCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.
Gustavo G NascimentoNational Dental Research Institute Singapore, National Dental Centre Singapore, Singapore 168938, Singapore.
Xinru WangCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.
Fabio Renato Manzolli LeiteNational Dental Research Institute Singapore, National Dental Centre Singapore, Singapore 168938, Singapore.
Bibhas ChakrabortyCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.
Chuan HongDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, United States.
Yilin NingCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.
Feng XieCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.
Zhen Ling TeoSingapore National Eye Centre, Singapore, Singapore Eye Research Institute, Singapore 168751, Singapore.
Daniel Shu Wei TingCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.
Hamed HaddadiDepartment of Computing, Imperial College London, London SW7 2AZ, England, United Kingdom.
Marcus Eng Hock OngProgramme in Health Services and Systems Research, Duke-NUS Medical School, Singapore 169857, Singapore.
Marco Aurélio PeresNational Dental Research Institute Singapore, National Dental Centre Singapore, Singapore 168938, Singapore.
Nan LiuCentre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.

Funding

Duke/Duke-NUS Collaboration grantDuke-NUS Collaboration
6 · The paper itself

Abstract

objectivesFederated learning (FL) has gained popularity in clinical research in recent years to facilitate privacy-preserving collaboration. Structured data, one of the most prevalent forms of clinical data, has experienced significant growth in volume concurrently, notably with the widespread adoption of electronic health records in clinical practice. This review examines FL applications on structured medical data, identifies contemporary limitations, and discusses potential innovations. MATERIALS AND

methodsWe searched 5 databases, SCOPUS, MEDLINE, Web of Science, Embase, and CINAHL, to identify articles that applied FL to structured medical data and reported results following the PRISMA guidelines. Each selected publication was evaluated from 3 primary perspectives, including data quality, modeling strategies, and FL frameworks.

resultsOut of the 1193 papers screened, 34 met the inclusion criteria, with each article consisting of one or more studies that used FL to handle structured clinical/medical data. Of these, 24 utilized data acquired from electronic health records, with clinical predictions and association studies being the most common clinical research tasks that FL was applied to. Only one article exclusively explored the vertical FL setting, while the remaining 33 explored the horizontal FL setting, with only 14 discussing comparisons between single-site (local) and FL (global) analysis.

conclusionsThe existing FL applications on structured medical data lack sufficient evaluations of clinically meaningful benefits, particularly when compared to single-site analyses. Therefore, it is crucial for future FL applications to prioritize clinical motivations and develop designs and methodologies that can effectively support and aid clinical practice and research.

Indexed as

Electronic Health RecordsLearningData AccuracyDatabases, FactualMotivationclinical decision-makingdistributed algorithmsdistributed learningelectronic health recordsfederated learning

Identifiers

PMID37639629
PMCPMC10654866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.