Evidence map›Paper›PMID 37639601›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2023

Acetylcholine and noradrenaline enhance foraging optimality in humans.

Nick Doren, Hui-Kuan Chung, Marcus Grueschow, Boris B Quednow, Helen Hayward-Könnecke, Alexander Jetter, Philippe N Tobler

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nick DorenDepartment of Economics, Laboratory for Social and Neural Systems Research, University of Zurich, Zurich 8006, Switzerland.ORCID 0000-0002-9868-5399
Hui-Kuan ChungDepartment of Economics, Laboratory for Social and Neural Systems Research, University of Zurich, Zurich 8006, Switzerland.ORCID 0000-0002-6030-1767
Marcus GrueschowDepartment of Economics, Laboratory for Social and Neural Systems Research, University of Zurich, Zurich 8006, Switzerland.
Boris B QuednowExperimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich 8008, Switzerland.ORCID 0000-0001-7933-2865
Helen Hayward-KönneckeDepartment of Neurology, Section of Neuroimmunology and Multiple Sclerosis Research, University Hospital Zurich, Zurich 8091, Switzerland.
Alexander JetterNational Poisons Information Centre, Tox Info Suisse, Associated Institute of the University of Zurich, Zurich 8032, Switzerland.ORCID 0000-0002-7394-2192
Philippe N ToblerDepartment of Economics, Laboratory for Social and Neural Systems Research, University of Zurich, Zurich 8006, Switzerland.ORCID 0000-0002-4915-9448
University of Zurich · CHUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foraging theory prescribes when optimal foragers should leave the current option for more rewarding alternatives. Actual foragers often exploit options longer than prescribed by the theory, but it is unclear how this foraging suboptimality arises. We investigated whether the upregulation of cholinergic, noradrenergic, and dopaminergic systems increases foraging optimality. In a double-blind, between-subject design, participants (N = 160) received placebo, the nicotinic acetylcholine receptor agonist

Indexed as

AcetylcholineMethylphenidateDouble-Blind MethodHumansNicotineNorepinephrineReboxetineAcetylcholineMethylphenidateNicotineNorepinephrineReboxetinecognitive enhancersexplorationmarginal value theoremstay-or-switchvalue-based decision-making

Identifiers

PMID37639601
PMCPMC10483619
OpenAlexW4386211768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.