Evidence map›Paper›PMID 37639365›Full record

ArticleJournal of the American Chemical Society2023

Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks.

Selina S Hess, Francesco Coppola, Viet Thuc Dang, Phuong Nguyen Tran, Philip J Mickel, Julia Oktawiec, Zhong Ren, Petr Král, Andy I Nguyen

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Discrete Actuation of Water-Responsive Crystalline Metal-Peptide Frameworks.Angewandte Chemie (International ed. in English) · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Selina S HessDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Francesco CoppolaDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-2429-204X
Viet Thuc DangDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Phuong Nguyen TranDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Philip J MickelDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Julia OktawiecDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-2895-3327
Zhong RenDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0001-7098-3127
Petr KrálDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0003-2992-9027
Andy I NguyenDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0003-4137-6453

Funding

Structural and Functional Synthetic Proteomimetics of Ankyrin Repeat ProteinsF32GM143925 · NIGMS · NORTHWESTERN UNIVERSITY · PI OKTAWIEC, JULIA · 2022 to 2023
$139k
NIGMS NIH HHS F32 GM143925
6 · The paper itself

Abstract

Though thiols are exceptionally versatile, their high reactivity has also hindered the synthesis and characterization of well-defined thiol-containing porous materials. Leveraging the mild conditions of the noncovalent peptide assembly, we readily synthesized and characterized a number of frameworks with thiols displayed at many unique positions and in several permutations. Importantly, nearly all assemblies were structurally determined using single-crystal X-ray diffraction to reveal their rich sequence-structure landscape and the cooperative noncovalent interactions underlying their assembly. These observations and supporting molecular dynamics calculations enabled rational engineering by the positive and negative design of noncovalent interactions. Furthermore, the thiol-containing frameworks undergo diverse single-crystal-to-single-crystal reactions, including toxic metal ion coordination (e.g., Cd

Identifiers

PMID37639365
PMCPMC12057566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.