ArticleEuropean heart journal2023
Prevalence and incidence of diastolic dysfunction in atrial fibrillation: clinical implications.
Article in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Impact of vascular and cardiac parameters on quality of life in patients undergoing catheter ablation for atrial fibrillation.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Review
- Right Ventricular-Pulmonary Artery Coupling in Patients With Atrial Fibrillation and Changes After Catheter Ablation.Journal of the American Heart Association · 2026Article
- The diagnosis and subclassification of heart failure with preserved ejection fraction: a review.Heart failure reviews · 2026Review
- Atrial fibrillation, sinoatrial and atrioventricular node dysfunction in a mouse model of heart failure with preserved ejection fraction.Experimental physiology · 2026Article
- Tricuspid Regurgitation Across the Spectrum of Heart Failure With Preserved Ejection Fraction.Journal of the American College of Cardiology · 2025Article
- Deriving novel atrial fibrillation phenotypes using a tree-based artificial intelligence-enhanced electrocardiography approach.NPJ digital medicine · 2025Article
- Discordance between left atrial pressure and risk scores in assessment of heart failure with preserved ejection fraction in patients with atrial fibrillation undergoing catheter ablation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Heart failure with preserved ejection fraction and atrial fibrillation: epidemiology, pathophysiology, and diagnosis interplay.Heart failure reviews · 2025Review
- Cardiovascular resource utilization in patients with diastolic dysfunction: A retrospective cohort analysis.American heart journal plus : cardiology research and practice · 2025Article
- Impact of coronary artery calcium on progression of diastolic dysfunction: a cohort study.BMC medicine · 2025Article
- Lessons From a Complex Case of Calcific Constrictive Pericarditis: A Case Report.Case reports in cardiology · 2025Article
- Comprehensive bioinformatics analysis of hub genes in ischemic heart failure and atrial fibrillation.Frontiers in cardiovascular medicine · 2025Article
- Advances in pathophysiological mechanisms and therapeutic efficacy of exercise rehabilitation in patients with heart failure with preserved ejection fraction.Frontiers in cardiovascular medicine · 2025Review
- Development and validation of a predictive model for left ventricular diastolic improvement following catheter ablation in atrial fibrillation with diastolic dysfunction: a retrospective analysis.Frontiers in cardiovascular medicine · 2025Article
- The predictive value of CHA2DS2-VASc score on the prognosis of patients with atrial fibrillation based on a prospective cohort study.Journal of thoracic disease · 2024Article
- Atrial fibrillation: age at diagnosis, incident cardiovascular events, and mortality.European heart journal · 2024Article
- Macrophage IL-1β mediates atrial fibrillation risk in diabetic mice.JCI insight · 2024Article
- The Role of Epicardial Adipose Tissue-Derived Proteins in Heart Failure with Preserved Ejection Fraction and Atrial Fibrillation: A Bioinformatics Analysis.Journal of inflammation research · 2024Article
- Staging Heart Failure with Preserved Ejection Fraction by Assessing Cardiac Chamber Involvement.European cardiology · 2024Review
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8 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsAtrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are intimately associated disorders; HFpEF may be overlooked in AF when symptoms are simply attributed to dysrhythmia, and incident AF may identify patients at risk for developing diastolic dysfunction (DD). This study aimed to investigate the prevalence and incidence of DD in patients with new-onset AF compared with sinus rhythm (SR).
methodsAdults with new-onset AF (n = 1747) or SR (n = 29 623) and no structural heart disease were identified. Propensity score matching was performed (1:3 ratio) between AF and SR based on age, sex, body mass index, and comorbidities. Severe DD (SDD) was defined by ≥3/four abnormal parameters (medial e', medial E/e', tricuspid regurgitation velocity, and left atrial volume index) and ≥moderate DD (>MDD) by ≥2/4. Annualized changes in DD indices were determined.
resultsNew-onset AF was independently associated with SDD (8% vs. 3%) and ≥MDD (25% vs. 16%); 62% of patients with AF had high-risk H2FPEF scores, and 5% had clinically recognized HFpEF. Over a median follow-up of 3.2 (interquartile range 1.6-5.8) years, DD progressed two-four-fold more rapidly in those with new-onset AF (P < .001 for all). The risk for incident DD was increased in new-onset AF [hazard ratio (95% confidence interval) 2.69 (2.19-3.32) for SDD and 1.73 (1.49-2.02) for ≥MDD].
conclusionsPatients with new-onset AF display high-risk features for HFpEF at diagnosis, emphasizing the importance of evaluating for HFpEF among symptomatic patients with AF. Patients with new-onset AF have accelerated progression in DD over time, which may identify patients with preclinical HFpEF, where preventive therapies may be tested.
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