Evidence map›Paper›PMID 37639162›Full record

ArticleInflammopharmacology2023

Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties.

Marcel da Silva Nascimento, Péligris H Dos Santos, Fabiula F de Abreu, Andrea Y K V Shan, Ricardo G Amaral, Luciana N Andrade, Eliana B Souto, Matheus I S Santos, Ariel de Souza Graça, Jesica B Souza and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Inflammopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. The Lectin fromInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Comparative Study on Antioxidant Potential ofMolecules (Basel, Switzerland) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Marcel da Silva NascimentoGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Péligris H Dos SantosGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Fabiula F de AbreuGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Andrea Y K V ShanDepartment of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Ricardo G AmaralGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil. ricardoamaral23@hotmail.com.
Luciana N AndradeGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Eliana B SoutoUCIBIO-Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal. ebsouto@ff.up.pt.ORCID http://orcid.org/0000-0002-9737-6017
Matheus I S SantosGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Ariel de Souza GraçaGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Jesica B SouzaGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Joanda P Raimundo E SilvaHealth Sciences Center, Postgraduate Program in Natural and Synthetic Bioactive Products, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, 58051-970, Brazil.
Josean F TavaresHealth Sciences Center, Postgraduate Program in Natural and Synthetic Bioactive Products, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, 58051-970, Brazil.
Ana M de Oliveira E SilvaDepartment of Nutrition, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Cristiane B CorreaGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Monalisa M MontalvãoDepartment of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Sonia PiacenteDepartment of Pharmacy, University of the Study of Salerno, Via Giovanni Paolo II n. 132, 84084, Fisciano, Salerno, Italy.
Cosimo PizzaDepartment of Pharmacy, University of the Study of Salerno, Via Giovanni Paolo II n. 132, 84084, Fisciano, Salerno, Italy.
Enilton A CamargoGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Charles Dos Santos EstevamGraduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, 49000-100, Brazil.
Universidade Federal de Sergipe · BRUniversidade Federal da Paraíba · BRUniversity of Salerno · ITUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC-MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical (EC

Indexed as

AnacardiaceaeAntioxidantsAnimalsAnti-Inflammatory AgentsBrazilMicePlant ExtractsPlant LeavesQuercetinSchinusAnti-Inflammatory AgentsAntioxidantsPlant ExtractsQuercetinCytokinesInflammationMedicinal plantOxidative stressPhenolic compoundsSchinus terebinthifolius

Identifiers

PMID37639162
PMCPMC10518276
OpenAlexW4386208964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.