ArticleBreast cancer research and treatment2023
Association of body composition and surgical outcomes in patients with early-stage breast cancer.
Article in Breast cancer research and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 10 citations in OpenAlex.
- Low pectoralis major muscle mass predicts the risk of post-surgical bleeding after mastectomy in patients with breast cancer.Breast cancer research and treatment · 2026Article
- Deep Learning-Derived Body Composition Analysis Predicts Long-Term Mortality After Transcatheter Aortic Valve Replacement.Mayo Clinic proceedings. Digital health · 2026Article
- Association of computed tomography-derived body composition with surgical and oncologic outcomes in periampullary adenocarcinoma.Surgical endoscopy · 2026Article
- High burden of geriatric assessment impairments across the adult age spectrum in patients with cancer.The oncologist · 2026Article
- Sarcopenia in breast cancer: prognostic values and emerging therapeutic strategies.Frontiers in surgery · 2026Review
- The relationship between sarcopenia and breast cancer: mechanistic pathways and clinical relevance.Frontiers in cell and developmental biology · 2026Review
- Post-Operative Atrial Fibrillation: Novel Predictive Value of CT-Derived Adipose Tissue Density in Minimally Invasive Mitral Surgery.Physiological research · 2025Article
- A pilot study of pre-diagnosis dietary patterns and lifestyle factors in physically active and inactive women with breast cancer.Scientific reports · 2025Article
- Article
- Enhanced muscle and fat segmentation for CT-based body composition analysis: a comparative study.International journal of computer assisted radiology and surgery · 2024Article
- Enhanced Muscle and Fat Segmentation for CT-Based Body Composition Analysis: A Comparative Study.ArXiv · 2024Article
- Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundBreast cancer is a disease that requires multimodality treatment, and surgical resection of the tumor is a critical component of curative intent treatment. Obesity, defined as a body mass index (BMI) > 30, has been associated with increased surgical complications. Additionally, sarcopenia, a condition of gradual loss of muscle mass, has been associated with worse breast cancer treatment outcomes. Sarcopenia occurs with increased age, inactivity, and poor diet leading to patient frailty, which can increase medical treatment complications. Even patients with high BMI can have sarcopenia (termed sarcopenic obesity). We investigated the association of sarcopenia with surgical complications for breast cancer.
methodsA retrospective review was performed of patients diagnosed with breast cancer who received bioelectrical impedance spectrometry analysis of skeletal muscle mass and had surgery at our institution. Patient characteristics, treatment data, surgical type and complications were obtained from medical records. Multivariate logistic regression models were used to associate sarcopenia status and BMI with surgical complications, adjusted for other patient characteristics.
resultsWe analyzed 682 patients with stage I to III breast cancer. On multivariable logistic regression controlling for age, BMI, comorbidities, and types of surgeries (lumpectomy, mastectomy with or without reconstruction), sarcopenia (p = 0.66) was not associated with surgical complications. Obesity was associated with a higher rate of surgical complications in patients who received mastectomy with reconstruction (p = 0.01). More complex surgical approaches were associated with a higher risk of surgical complications in our series.
conclusionCompared with those undergoing lumpectomy or mastectomy without reconstruction, patients undergoing mastectomy with reconstruction were more likely to experience postoperative complications and obesity was associated with higher risk of complication in the latter group. We did not identify a correlation between sarcopenia and rate of adverse surgical outcomes.
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