Evidence map›Paper›PMID 37638454›Full record

ArticleNeuroRehabilitation2023

Effects of anodal tDCS on electroencephalography correlates of cognitive control in mild-to-moderate traumatic brain injury.

Nickolas Mertens, James Cavanagh, Emma Brandt, Violet Fratzke, Jacqueline Story-Remer, Rebecca Rieger, J Kevin Wilson, Darbi Gill, Richard Campbell, Davin K Quinn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroRehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nickolas MertensCenter for Brain Recovery and Repair, University of New Mexico, Albuquerque, NM, USA.
James CavanaghDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Emma BrandtCenter for Brain Recovery and Repair, University of New Mexico, Albuquerque, NM, USA.
Violet FratzkeCenter for Brain Recovery and Repair, University of New Mexico, Albuquerque, NM, USA.
Jacqueline Story-RemerCenter for Brain Recovery and Repair, University of New Mexico, Albuquerque, NM, USA.
Rebecca RiegerCenter for Brain Recovery and Repair, University of New Mexico, Albuquerque, NM, USA.
J Kevin WilsonCenter for Brain Recovery and Repair, University of New Mexico, Albuquerque, NM, USA.
Darbi GillCenter for Brain Recovery and Repair, University of New Mexico, Albuquerque, NM, USA.
Richard CampbellDepartment of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.
Davin K QuinnDepartment of Psychiatry and Behavioral Sciences, University of New Mexico, Albuquerque, NM, USA.
University of New Mexico · US

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
NIGMS NIH HHS P20 GM109089
6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) may provide a potential therapy for cognitive deficits caused by traumatic brain injury (TBI), yet its efficacy and mechanisms of action are still uncertain.

objectiveWe hypothesized that anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC) would boost the influence of a cognitive training regimen in a mild-to-moderate TBI (mmTBI) sample. Cognitive enhancement was measured by examining event-related potentials (ERPs) during cognitive control tasks from pre- to post-treatment.

methodsThirty-four participants with mmTBI underwent ten sessions of cognitive training with active (n = 17) or sham (n = 17) anodal tDCS to the left DLPFC. ERPs were assessed during performance of an auditory oddball (3AOB), N-back, and dot pattern expectancy (DPX) task before and after treatment.

resultsP3b amplitudes significantly decreased from baseline to post-treatment testing, regardless of tDCS condition, in the N-back task. The active tDCS group demonstrated a significantly increased P3a amplitude in the DPX task. No statistically significant stimulation effects were seen during the 3AOB and N-back tasks.

conclusionActive anodal tDCS paired with cognitive training led to increases in P3a amplitudes in the DPX, inferring increased cognitive control. P3b decreased in the N-back task demonstrating the effects of cognitive training. These dissociated P3 findings suggest separate mechanisms invoked by different neuroplasticity-inducing paradigms (stimulation versus training) in brain networks that support executive functioning.

Indexed as

Brain Injuries, TraumaticElectroencephalographyTranscranial Direct Current StimulationAdultCognitionDorsolateral Prefrontal CortexEvoked PotentialsExecutive FunctionFemaleHumansMaleMiddle AgedTreatment OutcomeYoung Adultcognitive controlelectroencephalographytranscranial direct current stimulationTraumatic brain injury

Identifiers

PMID37638454
PMCPMC11436288
OpenAlexW4386073867

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.