ArticleJournal of Alzheimer's disease : JAD2023
Microstructural Neurodegeneration of the Entorhinal-Hippocampus Pathway along the Alzheimer's Disease Continuum.
Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The application of diffusion tensor imaging in patients with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Submillimeter postmortem and in vivo diffusion and susceptibility magnetic resonance imaging to characterize cortical micro- and meso-structures.Research square · 2026Article
- Evolutionary implications ofBrain communications · 2026Article
- Hippocampal subregional texture features associated with Alzheimer's disease severity and cognition.Brain communications · 2026Article
- Imaging Developmental Trajectories of Laminar Magnetic Susceptibility Throughout Adulthood in Human Brain Cortex.Human brain mapping · 2025Article
- Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Fuzzy Optimized Attention Network with Multi-Instance Deep Learning (FOAN-MIDL) for Alzheimer's Disease Diagnosis with Structural Magnetic Resonance Imaging (sMRI).Diagnostics (Basel, Switzerland) · 2025Article
- Quantification of perforant path fibers for early detection of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Quantitative magnetic resonance imaging in Alzheimer's disease: a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Investigating the association between the GAP-43 concentration with diffusion tensor imaging indices in Alzheimer's dementia continuum.BMC neurology · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundConventional neuroimaging biomarkers for the neurodegeneration of Alzheimer's disease (AD) are not sensitive enough to detect neurodegenerative alterations during the preclinical stage of AD individuals.
objectiveWe examined whether neurodegeneration of the entorhinal-hippocampal pathway could be detected along the AD continuum using ultra-high-field diffusion tensor imaging and tractography for ex vivo brain tissues.
methodsPostmortem brain specimens from a cognitively unimpaired individual without AD pathological changes (non-AD), a cognitively unimpaired individual with AD pathological changes (preclinical AD), and a demented individual with AD pathological changes (AD dementia) were scanned with an 11.7T diffusion magnetic resonance imaging. Fractional anisotropy (FA) values of the entorhinal layer II and number of perforant path fibers counted by tractography were compared among the AD continuum. Following the imaging analyses, the status of myelinated fibers and neuronal cells were verified by subsequent serial histological examinations.
resultsAt 250μm (zipped to 125μm) isotropic resolution, the entorhinal layer II islands and the perforant path fibers could be identified in non-AD and preclinical AD, but not in AD dementia, followed by histological verification. The FA value of the entorhinal layer II was the highest among the entorhinal laminae in non-AD and preclinical AD, whereas the FA values in the entorhinal laminae were homogeneously low in AD dementia. The FA values and number of perforant path fibers decreased along the AD continuum (non-AD>preclinical AD > AD dementia).
conclusionWe successfully detected neurodegenerative alterations of the entorhinal-hippocampal pathway at the preclinical stage of the AD continuum.
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