SynthesisStroke2023
Extracranial Carotid Plaque Calcification and Cerebrovascular Ischemia: A Systematic Review and Meta-Analysis.
Synthesis in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Diagnostics Accuracy of Magnetic Resonance Imaging in Detection of Atherosclerotic Plaque Characteristics in Carotid Arteries Compared to Histology: A Systematic Review.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
- High-risk plaque characteristics associated with recurrent stroke in patients with intracranial stenosis: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- Hypointensity on Carotid Plaque MRI and Its Relationship to Calcification: Histopathologic Validation With Quantitative Susceptibility Mapping.Journal of magnetic resonance imaging : JMRI · 2026Article
- Covert macrovascular disease and early outcome after ischemic cerebrovascular events.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Observational
- Editorial for "Hypointensity on Carotid Plaque MRI and Its Relationship to Calcification: Histopathologic Validation With Quantitative Susceptibility Mapping".Journal of magnetic resonance imaging : JMRI · 2026Article
- Carotid plaque inflammation and calcification on somatostatin receptor PET/CT imaging predict stroke and major adverse cardiovascular events.European heart journal. Cardiovascular Imaging · 2026Article
- Plaque Prolapse in Carotid Artery Stenting: Mechanisms, Imaging and Device-Based Prevention.Medicina (Kaunas, Lithuania) · 2026Review
- Geometric and density relationships of calcification clusters in carotid atherosclerosis.The neuroradiology journal · 2026Article
- Multimodal Risk Stratification Clue of Carotid Bifurcation Plaques: A Cross-Sectional Observational Study of Vector Flow Imaging, Plaque-RADS, and Clinical Factors.Translational stroke research · 2026Observational
- Distinction between acute and chronic carotid disease based on computed tomography angiography in acute ischemic stroke patients with carotid artery occlusion.BMC neurology · 2026Article
- The Correlation between Inflammatory Markers and Carotid Atherosclerotic Plaque Characteristics.Cerebrovascular diseases extra · 2026Article
- Calcified nodules in the cervical carotid artery.Surgical neurology international · 2026Article
- Independent predictors of ischemic stroke: a comprehensive scan of the internal carotid and vertebrobasilar systems.Quantitative imaging in medicine and surgery · 2025Article
- Risk prediction for symptomatic ischemic cerebrovascular disease based on ultrasound indicators of carotid plaque neovascularization.Frontiers in cardiovascular medicine · 2025Article
- Quantification of carotid artery plaque and peri-vascular adipose tissue attenuation on computed tomography.European heart journal. Imaging methods and practice · 2025Article
- Extracranial carotid plaque calcification and its association with risk factors for cerebrovascular events: insights from the ANTIQUE study.Frontiers in neurology · 2025Article
- Amyloid beta is associated with carotid wall echolucency and atherosclerotic plaque composition.Scientific reports · 2024Article
- Correlation between Carotid Blood Flow Velocity and Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease in Patients with Recent Small Subcortical Infarcts.Current neurovascular research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough coronary calcification quantification is an established approach for cardiovascular risk assessment, the value of quantifying carotid calcification is less clear. As a result, we performed a systematic review and meta-analysis to evaluate the association between extracranial carotid artery plaque calcification burden and ipsilateral cerebrovascular ischemic events.
methodsA comprehensive literature search was performed in the following databases: Ovid MEDLINE(R) 1946 to July 6, 2022; OVID Embase 1974 to July 6, 2022; and The Cochrane Library (Wiley). We performed meta-analyses including studies in which investigators performed a computed tomography assessment of calcification volume, percentage, or other total calcium burden summarizable in a single continuous imaging biomarker and determined the association of these features with the occurrence of ipsilateral stroke or transient ischemic attack.
resultsOur overall meta-analysis consisted of 2239 carotid arteries and 9 studies. The presence of calcification in carotid arteries ipsilateral to ischemic stroke or in stroke patients compared with asymptomatic patients did not demonstrate a significant association with ischemic cerebrovascular events (relative risk of 0.75 [95% CI, 0.44-1.28];
conclusionsThe presence of calcification in carotid plaque confers a reduced association with ipsilateral ischemic events, although these results seem to be limited among carotid arteries with higher degrees of stenosis. Adoption of carotid calcification measures in clinical decision-making will require additional studies providing more reproducible and standardized methods of calcium characterization and testing these imaging strategies in prospective studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.