ReviewReproductive medicine and biology
Paracrine regulation of granulosa cell development in the antral follicles in mammals.
Review in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Follicle-stimulating hormone promotes energy metabolism in bovine granulosa cells through the FOXO1-ISG15 pathway to maintain the development of multiple follicles.Journal of animal science and biotechnology · 2026Article
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
- Dietary Supplementation with Raspberry or Strawberry Seed Oil Impacts Folliculogenesis, Hormonal Parameters and the Fatty Acid Profile in the Juvenile Rabbit Ovary.Animals : an open access journal from MDPI · 2026Article
- RNA-Seq Analysis of Human Cumulus Cells Identifies Angiogenic Pathways Associated with Infertility.Cells · 2026Article
- FGF receptor 2 signaling in granulosa cells is required for normal female fertility in mice.Reproduction (Cambridge, England) · 2025Article
- Impact of Neutral Sphingomyelinase Inhibition on Small Extracellular Vesicle Production by Mural Granulosa Cells and In Vitro Folliculogenesis in Mice.Molecular reproduction and development · 2025Article
- CCDC134 enhances ovarian reserve function and angiogenesis by directly interacting with INHA in a mouse model of premature ovarian insufficiency.Apoptosis : an international journal on programmed cell death · 2025Article
- The Differentiation Fate of Granulosa Cells and the Regulatory Mechanism in Ovary.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies.Cells · 2024Review
- Baicalin enhances proliferation and reduces inflammatory-oxidative stress effect in HBMC complementary medicine and therapies · 2024Article
- Current Status of In Vitro Oocyte Growth and Development in Mammals.Reproductive medicine and biologyReview
- TFAM-Mediated mtDNA Replication is Essential for Developmental Competence of In Vitro Grown Oocytes.Reproductive medicine and biologyArticle
- Paracrine regulation of granulosa cell development in the antral follicles in mammals.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Development of ovarian follicles is regulated by a complex interaction of intra- and extra-follicular signals. Oocyte-derived paracrine factors (ODPFs) play a central role in this process in cooperation with other signals. Methods: This review provides an overview of the recent advances in our understanding of the paracrine regulation of antral follicle development in mammals. It specifically focuses on the regulation of granulosa cell development by ODPFs, along with other intrafollicular signals. Main Findings: Bi-directional communication between oocytes and surrounding cumulus cells is a fundamental mechanism that determines cumulus cell differentiation. Along with estrogen, ODPFs promote the expression of forkhead box L2, a critical transcription factor required for mural granulosa cells. Follicle-stimulating hormone (FSH) facilitates these processes by stimulating estrogen production in mural granulosa cells. Conclusion: Cooperative interactions among ODPFs, FSH, and estrogen are critical in determining the fate of cumulus and mural granulosa cells, as well as the development of oocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.