Evidence map›Paper›PMID 37638129›Full record

ArticleJournal of fluorine chemistry2023

Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors.

Vladimir V Burmistrov, Christophe Morisseau, Tatyana K Shkineva, Dmitry V Danilov, Boris Gladkikh, Gennady M Butov, Robert R Fayzullin, Tatyana Ya Dutova, Bruce D Hammock, Igor L Dalinger

Abstract read
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In one paragraph

Article in Journal of fluorine chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vladimir V BurmistrovDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
Christophe MorisseauDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
Tatyana K ShkinevaN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Lenin Avenue, Moscow 119991, Russia.
Dmitry V DanilovDepartment of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, 42a Engels Street, Volzhsky, 404121, Russia.
Boris GladkikhDepartment of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, 42a Engels Street, Volzhsky, 404121, Russia.
Gennady M ButovDepartment of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (branch) Volgograd State Technical University, 42a Engels Street, Volzhsky, 404121, Russia.
Robert R FayzullinArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 8 Arbuzov Street, Kazan, 420088, Russia.
Tatyana Ya DutovaN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Lenin Avenue, Moscow 119991, Russia.
Bruce D HammockDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, 95616, USA.
Igor L DalingerN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Lenin Avenue, Moscow 119991, Russia.

Funding

Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
NIEHS NIH HHS R35 ES030443
6 · The paper itself

Abstract

A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.5 nM. 1-Adamantyl-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]urea (

Indexed as

adamantanehalogenated pyrazolesinhibitorsoluble epoxide hydrolaseurea

Identifiers

PMID37638129
PMCPMC10457016

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.