Evidence map›Paper›PMID 37637969›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2023

Quantitative Wide-Field Swept-Source Optical Coherence Tomography Angiography and Visual Outcomes in RAO.

Yifan Lu, Ying Cui, Ying Zhu, Edward S Lu, Rebecca Zeng, Itika Garg, Raviv Katz, Rongrong Le, Jay C Wang, Demetrios G Vavvas and 4 more

Open access · goldAbstract read
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
    Review
  3. Review
  4. Article
  5. Retinal Artery Occlusion: A Review of Current Management Practices.Journal of ophthalmic & vision research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Yifan Lu *Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Ying Cui *Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Ying Zhu *Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Edward S LuHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Rebecca ZengHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Itika GargHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.ORCID 0000-0002-9537-8561
Raviv KatzHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Rongrong LeHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Jay C WangHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Demetrios G VavvasHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
Deeba HusainHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.ORCID 0000-0002-8494-0950
Joan W MillerHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
David WuHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.
John B MillerHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Boston, MA, USA.ORCID 0000-0003-0109-9738
Massachusetts Eye and Ear Infirmary · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Retinal artery occlusion (RAO) is an ophthalmic emergency that can lead to poor visual outcomes and is associated with an increased risk of stroke and cardiovascular events. Wide-field swept-source OCT-A (WF SS-OCTA) can provide quick and non-invasive angiographic information with a wide field of view. Here, we looked for associations between OCT-A vascular imaging metrics and vision in RAO patients. Methods: Patients with diagnoses of central (CRAO) or branched retinal artery occlusion (BRAO) were included. 6mm × 6mm Angio and 15mm × 15mm AngioPlex Montage OCT-A images were obtained for both eyes in each patient using Zeiss Plex Elite 9000 WF SS-OCTA device. Each 6mm × 6mm image was divided into nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. Non-perfusion area (NPA) was manually measured using 15mm × 15mm images. A linear regression model was utilized to identify correlation between imaging metrics and vision. Results: Twenty-five subjects were included. For RAO eyes, there was a statistically significant inverse correlation between retinal thickness as well as superficial capillary plexus (SCP) vessel density (VD) and vision. An inverse correlation was found between deep capillary plexus (DCP) VD and vision without statistical significance. There was a positive correlation between choroidal thickness as well as choroidal volume and vision without statistical significance. No significant correlation was found between the metrics and vision in contralateral eyes. For NPA and vision, no significant correlation was identified. Conclusion: This is the first study to investigate the utility of WF SS-OCTA in RAO and to demonstrate correlations between retinal vascular imaging metrics and visual outcomes. The results of this study provide a basis to understand the structural changes involved in vision in RAO and may guide management of RAO and prevention of cerebral stroke and cardiovascular accidents.

Indexed as

ARI networkBRAOCRAOETDRSRAOWF SS-OCTA

Identifiers

PMID37637969
PMCPMC10460179
OpenAlexW4386052240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.