Evidence map›Paper›PMID 37637946›Full record

SynthesisFrontiers in nutrition2023

Metabolic syndrome in relation to dietary acid load: a dose-response meta-analysis of observational studies.

Sulieman Ibraheem Shelash Al-Hawary, Faris Mushabab, Shahabe Saquib Abullais, Raed H Althomali, Ebraheem Abdu Musad Saleh, Serar Nassir Alnajjar, Khulood H Oudaha, Rosario Mireya Romero-Parra, Beneen M Hussien, Nazila Garousi

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 5 countries.

Sulieman Ibraheem Shelash Al-HawaryDepartment of Business Administration, Business School, Al al-Bayt University, Mafraq, Jordan.
Faris MushababDepartment of Periodontics, Albaha University, Al Bahah, Saudi Arabia.
Shahabe Saquib AbullaisDepartment of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Raed H AlthomaliDepartment of Chemistry, College of Arts and Science, Prince Sattam Bin Abdulaziz University, Wadi Al-Dawasir, Saudi Arabia.
Ebraheem Abdu Musad SalehDepartment of Chemistry, College of Arts and Science, Prince Sattam Bin Abdulaziz University, Wadi Al-Dawasir, Saudi Arabia.
Serar Nassir AlnajjarCollege of Dentistry, Al-Bayan University, Baghdad, Iraq.
Khulood H OudahaPharmaceutical Chemistry Department, College of Pharmacy, Al-Ayen University, Nasiriyah, Iraq.
Rosario Mireya Romero-ParraDepartment of General Studies, Universidad Continental, Lima, Peru.
Beneen M HussienMedical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
Nazila GarousiDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Prince Sattam Bin Abdulaziz University · SAAl al-Bayt University · JOAl-Ayen UniversityAl Baha University · SAIraqi University · IQIsfahan University of Medical Sciences · IRKing Khalid University · SAUniversidad Continental · PE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Several studies have identified that dietary acid load (DAL) may be associated with the odds of metabolic syndrome (MetS); however, the evidence is inconclusive. This dose-response meta-analysis aimed to examine the relation of DAL to MetS. Methods: A systematic literature search was carried out in PubMed and Scopus up to April 2023 for pertinent studies evaluating the relation of DAL scores, including potential renal acid load (PRAL) and net endogenous acid production (NEAP), to the odds of MetS. The odds ratios (OR) with 95% confidence intervals (CI) were pooled using a random-effects meta-analysis to test the association. Results: Eight studies, with an overall sample size of 31,351 participants, were included in this meta-analysis. Higher DAL scores were significantly related to the elevated odds of MetS (NEAP: OR = 1.42, 95%CI = 1.12-1.79; PRAL: OR = 1.76, 95%CI = 1.11-2.78), with significant evidence of heterogeneity across studies. The linear dose-response analysis proposed that a 10 mEq/day elevation in NEAP and PRAL was linked to a 2% (OR = 1.02, 95%CI = 1.001-1.05) and 28% (OR = 1.28, 95%CI = 1.11-1.47) increased odds of MetS, respectively. No non-linear association was observed between MetS and NEAP (P-non-linearity = 0.75) and PRAL (P-non-linearity = 0.92). Conclusion: This study revealed a significant direct relationship between DAL and MetS. Therefore, lower acidogenic diets are suggested for the prevention of MetS.

Indexed as

dietary acid loadmeta-analysismetabolic syndromeNEAPPRAL

Identifiers

PMID37637946
PMCPMC10450920
OpenAlexW4385760459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.