ArticleChem2023
Iron-mediated modular decarboxylative cross-nucleophile coupling.
Article in Chem, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Decarboxylative functionalization strategy for rapid assembly of bifunctional adamantaneChemical science · 2026Article
- Decarboxylative carbonyl alkylative amination: A general and practical strategy for aliphatic amine synthesis.Science advances · 2026Article
- Photoinduced Multicomponent Difluoromethylation of Imines via Iron-Mediated Ligand-to-Metal Charge Transfer.Organic letters · 2026Article
- Synthesis of CJACS Au · 2026Article
- Photo-driven bifunctional iron-catalyzed one-pot assembling of indoles from arylamines and alkanes/carboxylic acids.Nature communications · 2026Article
- Oxygen migration into carbon-carbon single bonds by photochemical oxidation.Nature synthesis · 2026Article
- Carbon-Heteroatom Bond Formation via Photoinduced Decarboxylative Radical Coupling Reactions.ACS omega · 2025Review
- Preassembly-Controlled Radical Recombination at Bismuth: Decarboxylative C─N Coupling with Sulfonamides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Modular access to saturated bioisosteres of anilines via photoelectrochemical decarboxylative C(spNature communications · 2025Article
- Iron-Catalyzed Aerobic Carbonylation of Methane via Ligand-to-Metal Charge Transfer Excitation.Journal of the American Chemical Society · 2025Article
- Article
- Decarboxylative Cross-Coupling Enabled by Fe and Ni Metallaphotoredox Catalysis.Journal of the American Chemical Society · 2024Article
- Building Catalytic Reactions One Electron at a Time.Accounts of chemical research · 2024Article
- Iron photocatalysis via Brønsted acid-unlocked ligand-to-metal charge transfer.Nature communications · 2024Article
- Article
- Acridine photocatalysis enables tricomponent direct decarboxylative amine construction.Chemical science · 2024Article
- Decarboxylative stereoretentive C-N coupling by harnessing aminating reagent.Nature communications · 2024Article
- Multimodal Acridine Photocatalysis Enables Direct Access to Thiols from Carboxylic Acids and Elemental Sulfur.ACS catalysis · 2024Article
- Visible light mediated iron-catalyzed addition of oxamic acids to imines.RSC advances · 2024Article
- Electrophotocatalytic perfluoroalkylation by LMCT excitation of Ag(II) perfluoroalkyl carboxylates.Science (New York, N.Y.) · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Carboxylic acids are valuable building blocks for pharmaceutical discovery because of their chemical stability, commercial availability, and structural diversity. Decarboxylative coupling reactions enable versatile functionalization of these feedstock chemicals, but many of the most general methods require prefunctionalization of carboxylic acids with redox-active moieties. These internal oxidants can be costly, their installation impedes rapid library synthesis, and their use results in environmentally problematic organic byproducts. We report herein a method for the direct decarboxylative cross-coupling of native carboxylic acids with nucleophilic coupling partners mediated by inexpensive, terrestrially abundant, and nontoxic Fe(III) salts. This method involves an initial photochemical decarboxylation followed by radical-polar crossover, which enables the construction of diverse carbon-carbon, carbon-oxygen, and carbon-nitrogen bonds with remarkable generality.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.