ArticleMacromolecules2023
Continuous-Flow Laboratory SAXS for In Situ Determination of the Impact of Hydrophilic Block Length on Spherical Nano-Object Formation during Polymerization-Induced Self-Assembly.
Article in Macromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Time-Resolved SAXS Studies During the Synthesis of Hydrolytically Degradable Poly(ε-caprolactone)-Poly(N,N'-dimethylacrylamide) Diblock Copolymer Nanoparticles in Aqueous Media.Angewandte Chemie (International ed. in English) · 2026Article
- Self-Assembled Vesicles of Emissive Surfactants in Water: Structural Characterization and Photophysical Insights.The journal of physical chemistry. B · 2025Article
- A Versatile Flow Reactor Platform for Machine Learning Guided RAFT Synthesis, Amidation of Poly(Pentafluorophenyl Acrylate).Macromolecular rapid communications · 2025Article
- Article
- Cellulose-Based Hybrid Hydrogels for Tissue Engineering Applications: A Sustainable Approach.Gels (Basel, Switzerland) · 2025Review
- Self-driving laboratory platform for many-objective self-optimisation of polymer nanoparticle synthesis with cloud-integrated machine learning and orthogonal online analytics.Polymer chemistry · 2025Article
- Exploiting Online Spatially Resolved Dynamic Light Scattering and Flow-NMR for Automated Size Targeting of PISA-Synthesized Block Copolymer Nanoparticles.ACS polymers Au · 2025Article
- Capturing Dynamic Assembly of Nanoscale Proteins During Network Formation.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Navigating the Expansive Landscapes of Soft Materials: A User Guide for High-Throughput Workflows.ACS polymers Au · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In situ small-angle X-ray scattering (SAXS) is a powerful technique for characterizing block-copolymer nano-object formation during polymerization-induced self-assembly. To work effectively in situ, it requires high intensity X-rays which enable the short acquisition times required for real-time measurements. However, routine access to synchrotron X-ray sources is expensive and highly competitive. Flow reactors provide an opportunity to obtain temporal resolution by operating at a consistent flow rate. Here, we equip a flow-reactor with an X-ray transparent flow-cell at the outlet which facilitates the use of a low-flux laboratory SAXS instrument for in situ monitoring. The formation and morphological evolution of spherical block copolymer nano-objects was characterized during reversible addition fragmentation chain transfer polymerization of diacetone acrylamide in the presence of a series of poly(dimethylacrylamide) (PDMAm) macromolecular chain transfer agents with varying degrees of polymerization. SAXS analysis indicated that during the polymerization, highly solvated, loosely defined aggregates form after approximately 100 s, followed by expulsion of solvent to form well-defined spherical particles with PDAAm cores and PDMAm stabilizer chains, which then grow as the polymerization proceeds. Analysis also indicates that the aggregation number (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.