Evidence map›Paper›PMID 37637177›Full record

ArticlePeerJ2023

Crown-of-thorns starfish spines secrete defence proteins.

Adam K Hillberg, Meaghan K Smith, Blake S Lausen, Saowaros Suwansa-Ard, Ryan Johnston, Shahida A Mitu, Leah E MacDonald, Min Zhao, Cherie A Motti, Tianfang Wang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Adam K HillbergCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Meaghan K SmithCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Blake S LausenCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Saowaros Suwansa-ArdCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Ryan JohnstonCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Shahida A MituCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Leah E MacDonaldSchool of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Min ZhaoCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Cherie A MottiAustralian Institute of Marine Science, Townsville, Australia.
Tianfang WangCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Abigail ElizurCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
Keisuke NakashimaMarine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, Japan.
Noriyuki SatohMarine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, Japan.
Scott F CumminsCentre for Bioinnovation, University of the Sunshine Coast, Maroochydore, QLD, Australia.
University of the Sunshine Coast · AUOkinawa Institute of Science and Technology Graduate University · JPAustralian Institute of Marine Science · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The crown-of-thorns starfish (COTS; Methods: Brine shrimp lethality assays were used to confirm the secretion of spine toxin biomolecules. Histological analysis, followed by spine-derived proteomics helped to explain the source and identity of proteins, while quantitative RNA-sequencing and phylogeny confirmed target gene expression and relative conservation, respectively. Results: We demonstrate the lethality of COTS spine secreted biomolecules on brine shrimp, including significant toxicity using aboral spine semi-purifications of >10 kDa (

Indexed as

ArtemiaProteomicsAnimalsArthralgiaBiological AssayBiological TransportCrown-of-thorns starfishDefenceEchinodermPhospholipase A2PlancitoxinSpineVenom

Identifiers

PMID37637177
PMCPMC10448888
OpenAlexW4386030541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.