Evidence map›Paper›PMID 37636950›Full record

ArticleACS omega2023

Keratose Self-Cross-Linked Wound Dressing for Iron Sequestration in Chronic Wounds.

Anastasia Anceschi, Alessia Patrucco, Parag Bhavsar, Marina Zoccola, Mirko Tessari, Luca Erbazzi, Paolo Zamboni

Abstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anastasia AnceschiCNR-STIIMA, Italian National Research Council, Institute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing, Corso G. Pella 16, 13900 Biella, Italy.
Alessia PatruccoCNR-STIIMA, Italian National Research Council, Institute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing, Corso G. Pella 16, 13900 Biella, Italy.ORCID https://orcid.org/0000-0002-6105-0226
Parag BhavsarCNR-STIIMA, Italian National Research Council, Institute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing, Corso G. Pella 16, 13900 Biella, Italy.
Marina ZoccolaCNR-STIIMA, Italian National Research Council, Institute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing, Corso G. Pella 16, 13900 Biella, Italy.ORCID https://orcid.org/0000-0002-5356-4817
Mirko TessariVascular Diseases Center, University of Ferrara, 44121 Ferrara, Italy.
Luca ErbazziVascular Diseases Center, University of Ferrara, 44121 Ferrara, Italy.
Paolo ZamboniVascular Diseases Center, University of Ferrara, 44121 Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wound diseases affect a large part of the world population, and therefore, novel treatments are becoming fundamental. People with chronic wounds show high iron and protease levels due to genetic disorders or other comorbidities. Since it was demonstrated that iron plays an important role in chronic wounds, being responsible for oxidative processes (ROS generation), while metalloproteinases prevent wound healing by literally "eating" the growing skin, it is crucial to design an appropriate wound dressing. In this paper, a novel bioactive dressing for binding iron in chronic wounds has been produced. Wool-derived keratose wound dressing in the form of films has been prepared by casting an aqueous solution of keratoses. These films are water-soluble; therefore, in order to increase their stability, they have been made insoluble through a thermal cross-link treatment. Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analyzer (TGA) analyses clarified the structure and the properties of the keratose wound dressing films. The capability of this new biomaterial in iron sequestration has been investigated by testing the adsorption of Fe

Identifiers

PMID37636950
PMCPMC10448490

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.