Evidence map›Paper›PMID 37636898›Full record

ArticleOrganic chemistry frontiers : an international journal of organic chemistry2023

Determination of Enantiomeric Excess and Diastereomeric Excess via Optical Methods. Application to α-methyl-β-hydroxy-carboxylic acids.

Sarah R Moor, James R Howard, Brenden T Herrera, Matthew S McVeigh, Federico Marini, Adrian T Keatinge-Clay, Eric V Anslyn

Abstract read
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In one paragraph

Article in Organic chemistry frontiers : an international journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah R MoorDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
James R HowardDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Brenden T HerreraDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Matthew S McVeighDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Federico MariniDepartment of Chemistry, University of Rome "La Sapienza", P.le Aldo Moro 5, Rome I-00185, Italy.
Adrian T Keatinge-ClayDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Eric V AnslynDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, USA.

Funding

Refining & Implementing Supramolecular Methods for HTS of EE & ConcentrationR01GM077437 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ANSLYN, ERIC V. · 2006 to 2021
$3.4M
Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529k
NIGMS NIH HHS R01 GM077437NIH HHS S10 OD021508
6 · The paper itself

Abstract

Characterization of chiral molecules in solution is paramount for measuring reaction success. However, techniques to distinguish between chiral molecules containing more than one stereocenter through the use of optical techniques remains a challenge. Herein, we report a techique using a series of circular dichroism spectra to train multivariate regression models that are capable of predicting the complete speciation of 3-hydroxy-2-methylbutanoic acid stereoisomers. From this, it is possible to rapidly and accurately determine the enantiomeric excess and diastereomeric excess of the solution without the need for chiral chromatography.

Identifiers

PMID37636898
PMCPMC10456989

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.