ArticleFrontiers in medicine2023
Associations between smoke exposure and kidney stones: results from the NHANES (2007-2018) and Mendelian randomization analysis.
Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Erectile dysfunction increases the risk of stroke: evidence from NHANES and Mendelian randomization analysis.Translational andrology and urology · 2025Article
- Article
- Association between Two Cardiovascular Health Algorithms and Kidney Stones: A Nationwide Cross-sectional Study.European urology open science · 2025Article
- Prevalence of Urinary Stones and Their Associated Risk Factors in the Jazan Region of Saudi Arabia.Cureus · 2025Article
- Association between life's crucial 9 and kidney stones: a population-based study.Frontiers in medicine · 2025Article
- Lipid metabolism disorders and albuminuria risk: insights from National Health and Nutrition Examination Survey 2001-2018 and Mendelian randomization analyses.Renal failure · 2024Article
- Identifying effects of volatile organic compounds exposure on kidney stone prevalence in U.S. adults: a cross-sectional analysis of NHANES 2007-2020.BMC public health · 2024Article
- Red blood cell folate level is associated with periodontitis in American adults: results from the NHANES 2009-2014.BMC oral health · 2024Article
- Prevalence and related factors of nephrolithiasis among medical staff in Qingdao, China: a retrospective cross-sectional study.BMC nephrology · 2024Article
- The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease-A State-of-the-Art Review.Nutrients · 2024Review
- Association between kidney stones and life's essential 8: a population-based study.World journal of urology · 2024Article
- Self-Reported Symptoms of Obstructive Sleep Apnea are Associated with Increased Risk of Kidney Stones: A Cross-Sectional Study from NHANES 2015-2020.Nature and science of sleep · 2024Article
- The complex relationship between vitamin D and kidney stones: balance, risks, and prevention strategies.Frontiers in nutrition · 2024Review
- Association between triglyceride glucose index-related indices and kidney stones in adults based on NHANES 2007-2020.Frontiers in endocrinology · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: It is currently controversial whether smoke exposure is associated with the risk of kidney stones. Herein, publicly available databases were combined to explore relationships with the risk of nephrolithiasis in terms of smoking status and serum cotinine concentrations. Materials and methods: First, we conducted an observational study using data from 2007 to 2018, based on the National Health and Nutrition Examination Survey (NHANES) database. Univariate analysis, multivariate logistic regression, trend testing, restricted cubic spline (RCS), and multiple imputation (MI) were the main analytical methods of our study. Then, A Mendelian randomization (MR) analysis was performed to explore the causal relationship between serum cotinine and nephrolithiasis. Genetic instruments for serum cotinine and pooled data for kidney stones were derived from publicly available large-scale genome-wide association studies (GWAS). Inverse-variance weighting (IVW) was the primary method for our MR analysis. Results: A total of 34,657 and 31,352 participants were included in the observational study based on smoking status and serum cotinine concentrations, respectively. Under full adjustment of covariates, current smokers had an increased risk of kidney stones compared to non-smokers [OR = 1.17 (1.04-1.31), Conclusion: Current smoking and high serum cotinine concentrations may be associated with an increased risk of kidney stones. Further research is needed to validate this relationship and explore its underlying mechanisms.
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