ArticleAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2021
Ileal Pouch-anal Anastomosis Complications and Pouch Failure: A systematic review and meta-analysis.
Article in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- PAVFCOS: The development of a core outcome set for pouch anal and vaginal fistula.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- Prevalence of 'pouch failure' of the ileoanal pouch in ulcerative colitis: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Capturing quality of life in pouch anal and vaginal fistula: development of PAVF-QoL-14, a patient-reported outcome measure.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Short- and long-term outcomes of IPAA for ulcerative colitis in Latin America: A retrospective, multicentre assessment.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Biological therapies for inflammatory pouch disorders: insights and outcomes from the RESERVO study of GETECCU.Therapeutic advances in gastroenterology · 2026Article
- The virtual colorectal surgical trainer-ileal pouch-anal anastomosis simulator shows evidence of validity.Surgical endoscopy · 2026Article
- Anastomotic Leak Following Colorectal Surgery.Clinics in colon and rectal surgery · 2026Review
- Article
- One-year stoma-free survival of ileoanal pouches for UC in European centers: The MIRACLE project.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Incidence, Risk Factors, and Outcomes of Chronic Antibiotic-Refractory Pouchitis in Korean Patients with Ulcerative Colitis.Gut and liver · 2025Article
- Bedside endoscopic inspection of colorectal anastomoses in the early postoperative period: a 2-center prospective feasibility study.Annals of coloproctology · 2025Article
- Review
- Pouchitis unveiled: exploring clinical features, diagnosis, and cutting-edge treatments.Therapeutic advances in gastroenterology · 2025Review
- Ileal pouch-anal anastomosis for ulcerative colitis: 30-year analysis on surgical evolution and patient outcome.BJS open · 2024Article
- Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: Predictors of Early and Late Complications.Cureus · 2024Article
- Diverting ileostomy for treatment of ileoanal pouch dysfunction: a technical note.International journal of colorectal disease · 2024Article
- Open vs. laparoscopic vs. robotic pouch excision: unveiling the best approach for optimal outcomes.Techniques in coloproctology · 2024Article
- Crohn's Disease of the Ileoanal Pouch: A High Rate of Potential Overdiagnoses.Inflammatory bowel diseases · 2024Article
- Are Small Molecules Effective in Treating Inflammatory Pouch Disorders Following Ileal Pouch-Anal Anastomosis for Ulcerative Colitis? Here Is Where We Stand.Biomolecules · 2024Review
- Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis.Journal of Crohn's & colitis · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review aims to assess the incidence of pouch failure and the correlation between ileal pouch-anal anastomosis (IPAA)-related complications and pouch failure. Background: Previous studies demonstrated wide variation in postoperative complication rates following IPAA. Methods: A systematic review was performed by searching the MEDLINE, EMBASE, and Cochrane Library databases for studies reporting on pouch failure published from January 1, 2010, to May 6, 2020. A meta-analysis was performed using a random-effects model, and the relationship between pouch-related complications and pouch failure was assessed using Spearman's correlations. Results: Thirty studies comprising 22,978 patients were included. Included studies contained heterogenic patient populations, different procedural stages, varying definitions for IPAA-related complications, and different follow-up periods. The pooled pouch failure rate was 7.7% (95% confidence intervals: 5.56-10.59) and 10.3% (95% confidence intervals: 7.24-14.30) for studies with a median follow-up of ≥5 and ≥10 years, respectively. Observed IPAA-related complications were anastomotic leakage (1-17%), pelvic sepsis (2-18%), fistula (1-30%), stricture (1-34%), pouchitis (11-61%), and Crohn's disease of the pouch (0-18%). Pelvic sepsis (r = 0.51, Conclusions: The single long-term determinant of pouch failure was pouch fistula, which is a manifestation of a chronic leak. Therefore, all effort should be taken to prevent an acute leak from becoming a chronic leak by early diagnosis and proactive management of the leak. Mini abstract: This systematic review aims to assess the incidence of pouch failure and the correlation between IPAA-related complications and pouch failure. Long-term pouch failure was correlated with fistula, suggesting that early septic complications may result in fistula formation during long-term follow-up, leading to an increased risk of pouch failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.