Evidence map›Paper›PMID 37636547›Full record

ReviewPhotoacoustics2023

Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.

Samuel John, Scott Hester, Maryam Basij, Avijit Paul, Marvin Xavierselvan, Mohammad Mehrmohammadi, Srivalleesha Mallidi

Abstract readReview
In one paragraph

Review in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
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  17. Ultrasound-responsive nanocarriers with siRNA and FeJournal of nanobiotechnology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samuel JohnDepartment of Biomedical Engineering, Wayne State University, Detroit, MI, USA.
Scott HesterDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Maryam BasijDepartment of Biomedical Engineering, Wayne State University, Detroit, MI, USA.
Avijit PaulDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Marvin XavierselvanDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Mohammad MehrmohammadiDepartment of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA.
Srivalleesha MallidiDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.

Funding

Image-guided oxygen enhanced photodynamic therapy with multi-functional nanodroplets to improve head and neck cancer treatment outcomesR01CA266701 · NCI · TUFTS UNIVERSITY MEDFORD · PI Srivalleesha Mallidi · 2022 to 2026
$1.7M
Molecular, Functional, and Microstructural Imaging of Cervical Remodeling BiomarkersR01EB030058 · NIBIB · WAYNE STATE UNIVERSITY · PI MEHRMOHAMMADI, MOHAMMAD · 2020 to 2023
$1.6M
Biodegradable liquid metal nanoagents for photoacoustic image-guided photodynamic therapyR21CA263694 · NCI · TUFTS UNIVERSITY MEDFORD · PI MALLIDI, SRIVALLEESHA · 2022 to 2023
$399k
NCI NIH HHS R01 CA266701NCI NIH HHS R21 CA263694NIBIB NIH HHS R01 EB030058
6 · The paper itself

Abstract

In the past decade, photoacoustic (PA) imaging has attracted a great deal of popularity as an emergent diagnostic technology owing to its successful demonstration in both preclinical and clinical arenas by various academic and industrial research groups. Such steady growth of PA imaging can mainly be attributed to its salient features, including being non-ionizing, cost-effective, easily deployable, and having sufficient axial, lateral, and temporal resolutions for resolving various tissue characteristics and assessing the therapeutic efficacy. In addition, PA imaging can easily be integrated with the ultrasound imaging systems, the combination of which confers the ability to co-register and cross-reference various features in the structural, functional, and molecular imaging regimes. PA imaging relies on either an endogenous source of contrast (e.g., hemoglobin) or those of an exogenous nature such as nano-sized tunable optical absorbers or dyes that may boost imaging contrast beyond that provided by the endogenous sources. In this review, we discuss the applications of PA imaging with endogenous contrast as they pertain to clinically relevant niches, including tissue characterization, cancer diagnostics/therapies (termed as theranostics), cardiovascular applications, and surgical applications. We believe that PA imaging's role as a facile indicator of several disease-relevant states will continue to expand and evolve as it is adopted by an increasing number of research laboratories and clinics worldwide.

Indexed as

ClinicalDiagnosticsEndogenousImage-guidedInterventionsPhotoacousticsSpectroscopyTheranosticsUltrasound

Identifiers

PMID37636547
PMCPMC10448345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.