Evidence map›Paper›PMID 37636242›Full record

ArticleImmunotherapy advances2023

Lytic efficiency of immunosuppressive drug-resistant armoured T cells against circulating HBV-related HCC in whole blood.

Meiyin Lin, Sebastian Chakrit Bhakdi, Damien Tan, Joycelyn Jie Xin Lee, David Wai Meng Tai, Andrea Pavesi, Lu-En Wai, Tina Wang, Antonio Bertoletti, Anthony Tanoto Tan

Open access · goldAbstract read
In one paragraph

Article in Immunotherapy advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Meiyin LinEmerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Sebastian Chakrit BhakdiDepartment of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Damien TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.
Joycelyn Jie Xin LeeDivision of Medical Oncology, National Cancer Centre Singapore, Singapore.
David Wai Meng TaiDivision of Medical Oncology, National Cancer Centre Singapore, Singapore.
Andrea PavesiInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.
Lu-En WaiLion TCR Pte Ltd, Singapore.
Tina WangLion TCR Pte Ltd, Singapore.
Antonio BertolettiEmerging Infectious Diseases, Duke-NUS Medical School, Singapore.ORCID https://orcid.org/0000-0002-2942-0485
Anthony Tanoto TanEmerging Infectious Diseases, Duke-NUS Medical School, Singapore.ORCID https://orcid.org/0000-0003-0079-8203
Agency for Science, Technology and Research · SGDuke-NUS Medical School · SGMahidol University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrence of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) after liver transplant (LT) is mediated by circulating tumour cells (CTCs) and exacerbated by the immunosuppressants required to prevent graft rejection. To circumvent the effects of immunosuppressants, we developed immunosuppressive drug-resistant armoured HBV-specific T-cell receptor-redirected T cells (IDRA HBV-TCR). However, their ability to eliminate HBV-HCC circulating in the whole blood has never been tested, and whether their lytic efficacy is compatible with the number of adoptively transferred T cells

Indexed as

adoptive T-cell transfercirculating tumour cellsHBVhepatocellular carcinomaTCR T cells

Identifiers

PMID37636242
PMCPMC10460197
OpenAlexW4385812462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.