Evidence map›Paper›PMID 37636207›Full record

ArticleBJUI compass2023

A randomised trial of [

Karen Middelbo Buch-Olsen, Mads Hvid Poulsen, Steinbjørn Hansen, Mie Holm Vilstrup, Jorun Holm, Søren Hess, Paw Christian Holdgaard, Karsten Egbert Arnold Zieger, Søren Sørensen Madsen, Oke Gerke and 9 more

Open access · goldAbstract read
In one paragraph

Article in BJUI compass, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. To see clear is not enough; it is the action that counts.Translational andrology and urology · 2024
    Article
  4. A randomised trial of [BJUI compass · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Karen Middelbo Buch-OlsenDepartment of Nuclear Medicine Odense University Hospital Odense C Denmark.ORCID https://orcid.org/0000-0002-6456-2593
Mads Hvid PoulsenDepartment of Clinical Research University of Southern Denmark Odense Denmark.ORCID https://orcid.org/0000-0002-7622-8402
Steinbjørn HansenDepartment of Oncology OUH Odense Odense C Denmark.ORCID https://orcid.org/0000-0001-5651-6493
Mie Holm VilstrupDepartment of Radiology and Nuclear Medicine The Hospital of South West Jutland Esbjerg Denmark.ORCID https://orcid.org/0000-0002-4760-0068
Jorun HolmDepartment of Nuclear Medicine Odense University Hospital Odense C Denmark.ORCID https://orcid.org/0000-0003-3607-8232
Søren HessDepartment of Radiology and Nuclear Medicine The Hospital of South West Jutland Esbjerg Denmark.ORCID https://orcid.org/0000-0003-1249-133X
Paw Christian HoldgaardDepartment of Nuclear Medicine Lillebaelt University Hospital of Southern Denmark Vejle Denmark.ORCID https://orcid.org/0000-0002-0122-0916
Karsten Egbert Arnold ZiegerDepartment of Urology Lillebaelt University Hospital of Southern Denmark Vejle Denmark.
Søren Sørensen MadsenDepartment of Urology The Hospital of South West Jutland Esbjerg Denmark.
Oke GerkeDepartment of Nuclear Medicine Odense University Hospital Odense C Denmark.ORCID https://orcid.org/0000-0001-6335-3303
Kasper Tholstrup PedersenDepartment of Nuclear Medicine Odense University Hospital Odense C Denmark.ORCID https://orcid.org/0000-0002-2036-7526
Johan Hygum DamDepartment of Nuclear Medicine Odense University Hospital Odense C Denmark.ORCID https://orcid.org/0000-0001-6577-7011
Niels LangkjærDepartment of Nuclear Medicine Odense University Hospital Odense C Denmark.ORCID https://orcid.org/0000-0002-8729-937X
Louise Dorner ØstergaardDepartment of Clinical Research University of Southern Denmark Odense Denmark.ORCID https://orcid.org/0000-0001-5981-367X
Jon Thor AsmussenDepartment of Radiology OUH Odense Odense C Denmark.ORCID https://orcid.org/0000-0003-0193-2005
Poul Erik BraadDepartment of Clinical Engineering Region of Southern Denmark Vejle Denmark.ORCID https://orcid.org/0000-0003-4906-5422
Birgitte NørgaardDepartment of Public Health University of Southern Denmark Odense C Denmark.ORCID https://orcid.org/0000-0002-2284-2335
Matthias EiberDepartment of Nuclear Medicine Technical University of Munich Munich Germany.
Malene Grubbe HildebrandtDepartment of Nuclear Medicine Odense University Hospital Odense C Denmark.ORCID https://orcid.org/0000-0003-2720-9018
University of Southern Denmark · DKOdense University Hospital · DKHospital South West Jutland · DKLillebaelt Hospital · DKOdense Municipality · DKRegion of Southern Denmark · DKTechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prostate-specific membrane antigen (PSMA)-positron emission tomography/contrast-enhanced computed tomography (PET/CT) is a sensitive imaging modality for prostate cancer (PCa). Due to lack of knowledge of the patient benefit, PSMA-PET/CT is not yet recommended in the European guidelines for staging and treatment planning of patients with newly diagnosed PCa. We will investigate the potential difference in progression-free survival (PFS) and quality of life (QoL) of using PSMA-PET/CT versus sodium fluoride (NaF)-PET/CT for staging and treatment planning in patients with newly diagnosed PCa. Study Design: This is a prospective randomised controlled multicentre trial carried out at three centres in the Region of Southern Denmark. Endpoints: The primary endpoint is PFS. Secondary endpoints are residual disease, stage migration, impact on treatment strategies, stage distribution, QoL and diagnostic accuracy measures. Patients and Methods: Patients eligible for the study have newly diagnosed unfavourable intermediate- or high-risk PCa. A total of 448 patients will be randomised 1:1 into two groups: (A) a control group staged with Na[ Trial Registration: The Regional Committees on Health Research Ethics for Southern Denmark (S-20190161) and the Danish Medicines Agency (EudraCT Number 2021-000123-12) approved the study, and it has been registered on clinicaltrials.gov (Record 2020110469).

Indexed as

primary prostate cancerprogression‐free survivalPSMA‐PET/CTquality of lifestaging

Identifiers

PMID37636207
PMCPMC10447207
OpenAlexW4382449261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.