Evidence map›Paper›PMID 37636064›Full record

ArticleiScience2023

Identifying shared transcriptional risk patterns between atherosclerosis and cancer.

Richard A Baylis, Hua Gao, Fudi Wang, Caitlin F Bell, Lingfeng Luo, Johan L M Björkegren, Nicholas J Leeper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Cancer Incidence After Diagnosis of Abdominal Aortic Aneurysm-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Richard A BaylisDepartment of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Hua GaoDepartment of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Fudi WangDepartment of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Caitlin F BellDepartment of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Lingfeng LuoDepartment of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Johan L M BjörkegrenDepartment of Medicine, Karolinska Institute, Huddinge, Sweden.
Nicholas J LeeperDepartment of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Clonal expansion, resistance to efferocytosis and innate immunity in atherosclerosisR35HL144475 · NHLBI · STANFORD UNIVERSITY · PI LEEPER, NICHOLAS JAMES · 2019 to 2024
$5.1M
NHLBI NIH HHS R35 HL144475
6 · The paper itself

Abstract

Cancer and cardiovascular disease (CVD) are the leading causes of death worldwide. Numerous overlapping pathophysiologic mechanisms have been hypothesized to drive the development of both diseases. Further investigation of these common pathways could allow for the identification of mutually detrimental processes and therapeutic targeting to derive mutual benefit. In this study, we intersect transcriptomic datasets correlated with disease severity or patient outcomes for both cancer and atherosclerotic CVD. These analyses confirmed numerous pathways known to underlie both diseases, such as inflammation and hypoxia, but also identified several novel shared pathways. We used these to explore common translational targets by applying the drug prediction software, OCTAD, to identify compounds that simultaneously reverse the gene expression signature for both diseases. These analyses suggest that certain tumor-specific therapeutic approaches may be implemented so that they avoid cardiovascular consequences, and in some cases may even be used to simultaneously target co-prevalent cancer and atherosclerosis.

Indexed as

Cardiovascular medicineClinical geneticsHealth sciencesTranscriptomics

Identifiers

PMID37636064
PMCPMC10448075

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.