Evidence map›Paper›PMID 37635967›Full record

ArticleFrontiers in endocrinology2023

CLK2 in GABAergic neurons is critical in regulating energy balance and anxiety-like behavior in a gender-specific fashion.

Sónia Norberto, Heloisa Balan Assalin, Dioze Guadagnini, Natália Tobar, Patrícia Aline Boer, Min-Cheol Kang, Mario Jose Abdalla Saad, Young-Bum Kim, Patricia Oliveira Prada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Sónia NorbertoDepartment of Internal Medicine, School of Medical Science, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Heloisa Balan AssalinDepartment of Internal Medicine, School of Medical Science, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Dioze GuadagniniDepartment of Internal Medicine, School of Medical Science, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Natália TobarDepartment of Radiology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Patrícia Aline BoerDepartment of Internal Medicine, Fetal Programming Laboratory, School of Medical Science, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Min-Cheol KangDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Mario Jose Abdalla SaadDepartment of Internal Medicine, School of Medical Science, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Young-Bum KimDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Patricia Oliveira PradaDepartment of Internal Medicine, School of Medical Science, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cdc2-like kinase (CLK2) is a member of CLK kinases expressed in hypothalamic neurons and is activated in response to refeeding, leptin, or insulin. Diet-induced obesity and leptin receptor-deficient Methods: We generated mice lacking Clk2 in Vgat-expressing neurons (Vgat-Cre; Clk2 Results and discussion: We showed that deletion of CLK2 in GABAergic neurons increased adiposity and food intake in females. The mechanisms behind these effects were likely due, at least in part, to hypothalamic insulin resistance and upregulation of hypothalamic Npy and Agrp expression. Besides normal insulin and pyruvate sensitivity, Vgat-Cre; Clk2

Indexed as

AnxietyEnergy MetabolismGABAergic NeuronsAnimalsFemaleInsulinsMaleMiceObesityProtein Serine-Threonine KinasesProtein-Tyrosine KinasesClk dual-specificity kinasesInsulinsProtein Serine-Threonine KinasesProtein-Tyrosine Kinasesanxiety-like behaviorCdc2-like kinaseCLK2food intake energy expenditureGABAergic neuronsglucose intolerancehypothalamus

Identifiers

PMID37635967
PMCPMC10449579
OpenAlexW4385717950

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.