Evidence map›Paper›PMID 37635362›Full record

ArticleGut microbes2023

Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell.

Xinhai Zhu, Ke Li, Guichao Liu, Ruan Wu, Yan Zhang, Siying Wang, Meng Xu, Ligong Lu, Peng Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 1 pooled it
25.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 1 synthesis or guideline pooled it, 162 citations in OpenAlex.

  1. Pooled it
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  6. Propionate promotes CD8Journal for immunotherapy of cancer · 2026
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Xinhai ZhuDepartment of Oncology, First Affiliated Hospital, Jinan University, Guangzhou, China.
Ke LiDepartment of Geriatrics, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Guichao LiuDepartment of Head and Neck Breast Radiotherapy, The First People's Hospital of Foshan City, Foshan, China.
Ruan WuCenter for Disease Control and Prevention, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
Yan ZhangDepartment of Oncology, First Affiliated Hospital, Jinan University, Guangzhou, China.
Siying WangDepartment of Breast Surgery, First Affiliated Hospital, Jinan University, Guangzhou, China.
Meng XuDepartment of Oncology, First Affiliated Hospital, Jinan University, Guangzhou, China.
Ligong LuGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Zhuhai, China.
Peng LiGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Zhuhai, China.ORCID 0000-0001-5518-9822
First Affiliated Hospital of Jinan University · CNJinan University · CNAnhui Provincial Center for Disease Control and Prevention · CNFirst People's Hospital of Foshan · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have demonstrated that the antitumor immunity of immune cells can be modulated by gut microbiota and their metabolites. However, the underlying mechanisms remain unclear. Here, we showed that the serum butyric acid level is positively correlated with the expression of programmed cell death-1 (PD-1) on circulating CD8

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungGastrointestinal MicrobiomeLung NeoplasmsAnimalsButyric AcidCD28 AntigensCD8-Positive T-LymphocytesHumansMiceReceptors, Antigen, T-CellSignal TransductionAntineoplastic AgentsButyric AcidCD28 AntigensReceptors, Antigen, T-Cellanti-tumor immunitybutyrateGut microbiotaPD-1T cell receptor

Identifiers

PMID37635362
PMCPMC10464552
OpenAlexW4386208749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.